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Chemical Structure| 90326-62-8 Chemical Structure| 90326-62-8

Structure of 90326-62-8

Chemical Structure| 90326-62-8

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Product Details of [ 90326-62-8 ]

CAS No. :90326-62-8
Formula : C9H9BrO3
M.W : 245.07
SMILES Code : O=C(OC)C1=CC=C(CO)C(Br)=C1
MDL No. :MFCD15527253
Boiling Point : No data available
InChI Key :FHBYEUICKVHSAL-UHFFFAOYSA-N
Pubchem ID :53419619

Safety of [ 90326-62-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 90326-62-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 90326-62-8 ]

[ 90326-62-8 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 908094-01-9 ]
  • [ 90050-64-9 ]
  • [ 90326-62-8 ]
  • 2
  • [ 90001-43-7 ]
  • [ 90326-62-8 ]
  • 3
  • 2-Bromo-1,4-bis-dibromomethyl-benzene [ No CAS ]
  • [ 90326-62-8 ]
  • 4
  • [ 104901-43-1 ]
  • [ 90326-62-8 ]
  • 5
  • [ 78946-25-5 ]
  • [ 90326-62-8 ]
  • 6
  • [ 1080573-21-2 ]
  • [ 90326-62-8 ]
YieldReaction ConditionsOperation in experiment
41.9% With methanol; sodium carbonate; at 20.0℃; for 1.0h; The crude product C2 (5.3g, 14.6mmol) was added to 20 mL MeOH and Na2CO3 (7.7g, 73mmol) was added and stirred at RT for 1h. TLC (Petroleum ether: EtOAc=10:1, Rf=0.1) showed the starting meterial was consumed completely. The reaction mixture was filtered and the filter cake was washed with MeOH. The combined filtrates were concentrated to dryness to give a crude product. The crude prouct was purified by silica gel chromatography to give product (1.5 g, 41.9%) as a white solid.
  • 7
  • [ 90326-62-8 ]
  • 3-bromo-4-[3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl]benzoic acid [ No CAS ]
  • 8
  • [ 90326-62-8 ]
  • (R)-3-bromo-N-(1-hydroxypropan-2-yl)-4-(((3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)oxy)methyl)benzamide [ No CAS ]
  • 9
  • [ 90326-62-8 ]
  • [ 215874-89-8 ]
  • 3-bromo-4-[3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl]benzoic acid methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium tert-butylate; In tetrahydrofuran; for 0.166667h;Inert atmosphere; To a solution of A1 (155 mg, 0.55 mmol) and C3 (200 mg, 0.82 mmol) in THF (60mL) was added t-BuOK (92 mg, 0.82 mmol) in portions during a period of 10 mins at 0 C under N2. After addition, the reaction mixture was stirred at 0 C for 0.5 h and then kept at RT for 1h. TLC (DCM: MeOH=20:1, Rf=0.4) showed the starting material was consumed completely. The reaction mixture was concentrated to dryness. The crud product was used directly in the next step without further purification
  • 10
  • [ 7697-26-9 ]
  • [ 90326-62-8 ]
 

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