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Chemical Structure| 898044-54-7 Chemical Structure| 898044-54-7

Structure of 898044-54-7

Chemical Structure| 898044-54-7

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Product Details of [ 898044-54-7 ]

CAS No. :898044-54-7
Formula : C18H26N6O
M.W : 342.44
SMILES Code : O=C(N1C(C)(C)C2=NNC(N)=C2C1)N[C@@H](C3=CC=CC=C3)CN(C)C

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Application In Synthesis of [ 898044-54-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 898044-54-7 ]

[ 898044-54-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 898044-54-7 ]
  • [ 1801-06-5 ]
  • C23H29FN8O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
32% With acetic acid; In water; at 100℃; for 1h; General conditions1: Chloropyrimidine 5 (0.45 mmol) and aminopyrazole 6 (0.30 mmol) were mixed in 1:1 acetic acid/water solution (1.4 mL) or in glacial acetic acid (1.4 mL) and stirred at 100 °C in an oil bath for 1 h (or 50 °C for 4 h or 25 °C for 18 h). The mixture was neutralized by the addition of ice-cold 5percent NaOH solution (10 mL) and extracted with methylene chloride (3 .x. 25 mL). Combined organic layers were dried and concentrated. The residue was further purified by normal phase flash chromatography (Biotage, for cPropylphenyl analogs R = C) or reversed phase preparative HPLC (analogs with free amines R = A or B), affording the desired aminopyrimidines (7-30).
 

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