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CAS No. : | 896466-04-9 |
Formula : | C19H23N7O2 |
M.W : | 381.43 |
SMILES Code : | O=C(NC1CC1)NC1=CNN=C1C1=NC2=C(N1)C=CC(CN1CCOCC1)=C2 |
MDL No. : | MFCD12031513 |
InChI Key : | LOLPPWBBNUVNQZ-UHFFFAOYSA-N |
Pubchem ID : | 135398495 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
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In Vitro:
Cell Line
| Concentration | Treated Time | Description | Reference |
HRCA-PDOs | 0.1 μM | 20 min | To identify the live and dead cells and nucleus and determine the inhibitory efficacy. | PMC10478412 |
human melanoma A375P cells | 0.25 µM | 24 hours | To evaluate the effect of AT9283 on the proliferation and migration of A375P cells, results showed that AT9283 significantly inhibited cell proliferation and migration. | PMC10932151 |
human melanoma A375P cells | 0.25 µM, 0.5 µM, 0.75 µM, 1 µM | 24 hours | To evaluate the effect of AT9283 on the cell cycle of A375P cells, results showed that AT9283 induced G1/S phase cell cycle arrest. | PMC10932151 |
A549 cells | 0 nM, 125 nM, 250 nM, 500 nM | 48 hours | AT9283 significantly inhibited the proliferation of A549 cells, and DLGAP5 overexpression significantly reversed the AT9283-induced cell proliferation suppression. | PMC10900829 |
H1299 cells | 0 nM, 125 nM, 250 nM, 500 nM | 48 hours | AT9283 significantly inhibited the proliferation of H1299 cells, and DLGAP5 overexpression significantly reversed the AT9283-induced cell proliferation suppression. | PMC10900829 |
HT29 cells | 50 nM | 72 h | AT9283 significantly inhibited cell proliferation, promoted autophagy and cell death, and reduced MKK3 protein levels. | PMC11334304 |
COLO205 cells | 15 nM | 72 h | AT9283 significantly inhibited cell proliferation, promoted autophagy and cell death, and reduced MKK3 protein levels. | PMC11334304 |
HCT116 cells | 50 nM | 72 h | AT9283 significantly inhibited cell proliferation, promoted autophagy and cell death, and reduced MKK3 protein levels. | PMC11334304 |
SW620 cells | 100 nM | 72 h | AT9283 significantly inhibited cell proliferation, promoted autophagy and cell death, and reduced MKK3 protein levels. | PMC11334304 |
SW480 cells | 1.6 μM | 72 h | AT9283 significantly inhibited cell proliferation, promoted autophagy and cell death, and reduced MKK3 protein levels. | PMC11334304 |
COLO320DM cells | 885 nM | 72 h | AT9283 significantly inhibited cell proliferation, promoted autophagy and cell death, and reduced MKK3 protein levels. | PMC11334304 |
CCD-18Co cells | 4 μM | 72 h | AT9283 had minimal effects on primary colonocytes and did not significantly affect MKK3 protein levels. | PMC11334304 |
In Vivo:
Species
| Animal Model
| Administration | Dosage | Frequency | Description | Reference |
BALB/c Nude mice | H1299 cell xenograft model | Intraperitoneal injection | 20 mg/kg | daily for 5 consecutive days, followed by a two-day interval, over a period of 3 weeks | AT9283 significantly inhibited tumor growth in the H1299 cell xenograft model and significantly reduced the protein levels of DLGAP5 and PLK1 in the tumors. | PMC10900829 |
Nude mice | COLO205 xenograft model | Gavage | 15 mg/kg | 5 days a week, until the end of the experiment | AT9283 significantly inhibited COLO205 tumor growth and reduced MKK3 and AURKA protein levels. | PMC11334304 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00985868 | Unspecified Childhood Solid Tu... More >>mor, Protocol Specific Less << | Phase 1 | Active, not recruiting | December 2018 | United Kingdom ... More >> Birmingham Children's Hospital Birmingham, England, United Kingdom, B4 6NH Leeds General Infirmary Leeds, England, United Kingdom, LS9 7TF Royal Manchester Children's Hospital Manchester, England, United Kingdom, M27 4HA Great North Children's Hospital, Royal Victoria Infirmary Newcastle-Upon-Tyne, England, United Kingdom, NE1 4LP Royal Marsden - Surrey Sutton, England, United Kingdom, SM2 5PT Less << |
NCT01431664 | Leukemia | Phase 1 | Completed | - | United Kingdom ... More >> Royal Marsden Hospital Surrey, London, United Kingdom, SM2 5PT Birmingham Children's Hospital Birmingham,, United Kingdom, B4 6NH Leeds General Infirmary Leeds, United Kingdom, LS1 3EX Royal Manchester Children's Hospital Manchester, United Kingdom, M13 9WL Great North Children's Hospital, Royal Victoria Infirmary Newcastle upon Tyne, United Kingdom, NE1 4LP Less << |
NCT00522990 | Acute Myeloid Leukemia|Acute L... More >>ymphoblastic Leukemia|Chronic Myeloid Leukemia|Myelodysplastic Syndromes|Myelofibrosis Less << | PHASE1|PHASE2 | TERMINATED | 2025-04-09 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35294, United States|The University of Texas, MD Anderson Cancer Center, Houston, Texas, 77030, United States Less << |
NCT00443976 | Non-Hodgkins Lymphoma ... More >> Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 1 | Completed | - | Canada, British Columbia ... More >> BCCA - Vancouver Cancer Centre Vancouver, British Columbia, Canada, V5Z 4E6 Canada, Ontario Ottawa Health Research Institute - General Division Ottawa, Ontario, Canada, K1H 8L6 Less << |
NCT01145989 | Multiple Myeloma | PHASE2 | COMPLETED | 2015-11-27 | Tom Baker Cancer Centre, Calga... More >>ry, Alberta, T2N 4N2, Canada|Cross Cancer Institute, Edmonton, Alberta, T6G 1Z2, Canada|Atlantic Health Sciences Corporation, Saint John, New Brunswick, E2L 4L2, Canada|QEII Health Sciences Center, Halifax, Nova Scotia, B3H 1V7, Canada|Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario, L8V 5C2, Canada|Univ. Health Network-Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada Less << |
Tags: AT9283 | AT 9283 | AT-9283 | JAK | Aurora Kinase | Bcr-Abl | FLT3 | Apoptosis | Autophagy | Janus kinase | Cluster of differentiation antigen 135 | CD135 | Fms like tyrosine kinase 3 | multi-targeted kinase inhibitor | Aurora B inhibitor | JAK2/3 inhibitor | Abl T315I | Flt3 inhibitor | kinase inhibition | Aurora A inhibitor | JAK3 inhibitor | JAK2 inhibitor | Abl T315I inhibitor | 896466-04-9
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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