Home Cart Sign in  
Chemical Structure| 893620-44-5 Chemical Structure| 893620-44-5

Structure of 893620-44-5

Chemical Structure| 893620-44-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 893620-44-5 ]

CAS No. :893620-44-5
Formula : C8H5BrFNO
M.W : 230.03
SMILES Code : O=C1NC2=C(C=C(F)C(Br)=C2)C1
MDL No. :MFCD16250437
InChI Key :YWZPDMAAXMNKIP-UHFFFAOYSA-N
Pubchem ID :58484246

Safety of [ 893620-44-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H317-H319
Precautionary Statements:P280-P305+P351+P338

Computational Chemistry of [ 893620-44-5 ] Show Less

Physicochemical Properties

Num. heavy atoms 12
Num. arom. heavy atoms 6
Fraction Csp3 0.12
Num. rotatable bonds 0
Num. H-bond acceptors 2.0
Num. H-bond donors 1.0
Molar Refractivity 49.39
TPSA ?

Topological Polar Surface Area: Calculated from
Ertl P. et al. 2000 J. Med. Chem.

29.1 Ų

Lipophilicity

Log Po/w (iLOGP)?

iLOGP: in-house physics-based method implemented from
Daina A et al. 2014 J. Chem. Inf. Model.

1.81
Log Po/w (XLOGP3)?

XLOGP3: Atomistic and knowledge-based method calculated by
XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry

1.56
Log Po/w (WLOGP)?

WLOGP: Atomistic method implemented from
Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.

1.93
Log Po/w (MLOGP)?

MLOGP: Topological method implemented from
Moriguchi I. et al. 1992 Chem. Pharm. Bull.
Moriguchi I. et al. 1994 Chem. Pharm. Bull.
Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.

2.29
Log Po/w (SILICOS-IT)?

SILICOS-IT: Hybrid fragmental/topological method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

2.92
Consensus Log Po/w?

Consensus Log Po/w: Average of all five predictions

2.1

Water Solubility

Log S (ESOL):?

ESOL: Topological method implemented from
Delaney JS. 2004 J. Chem. Inf. Model.

-2.62
Solubility 0.553 mg/ml ; 0.0024 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble
Log S (Ali)?

Ali: Topological method implemented from
Ali J. et al. 2012 J. Chem. Inf. Model.

-1.78
Solubility 3.81 mg/ml ; 0.0166 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Very soluble
Log S (SILICOS-IT)?

SILICOS-IT: Fragmental method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

-4.03
Solubility 0.0216 mg/ml ; 0.0000938 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Moderately soluble

Pharmacokinetics

GI absorption?

Gatrointestinal absorption: according to the white of the BOILED-Egg

High
BBB permeant?

BBB permeation: according to the yolk of the BOILED-Egg

Yes
P-gp substrate?

P-glycoprotein substrate: SVM model built on 1033 molecules (training set)
and tested on 415 molecules (test set)
10-fold CV: ACC=0.72 / AUC=0.77
External: ACC=0.88 / AUC=0.94

No
CYP1A2 inhibitor?

Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.83 / AUC=0.90
External: ACC=0.84 / AUC=0.91

Yes
CYP2C19 inhibitor?

Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.80 / AUC=0.86
External: ACC=0.80 / AUC=0.87

No
CYP2C9 inhibitor?

Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set)
and tested on 2075 molecules (test set)
10-fold CV: ACC=0.78 / AUC=0.85
External: ACC=0.71 / AUC=0.81

No
CYP2D6 inhibitor?

Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set)
and tested on 1068 molecules (test set)
10-fold CV: ACC=0.79 / AUC=0.85
External: ACC=0.81 / AUC=0.87

No
CYP3A4 inhibitor?

Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set)
and tested on 2579 molecules (test set)
10-fold CV: ACC=0.77 / AUC=0.85
External: ACC=0.78 / AUC=0.86

No
Log Kp (skin permeation)?

Skin permeation: QSPR model implemented from
Potts RO and Guy RH. 1992 Pharm. Res.

-6.6 cm/s

Druglikeness

Lipinski?

Lipinski (Pfizer) filter: implemented from
Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev.
MW ≤ 500
MLOGP ≤ 4.15
N or O ≤ 10
NH or OH ≤ 5

0.0
Ghose?

Ghose filter: implemented from
Ghose AK. et al. 1999 J. Comb. Chem.
160 ≤ MW ≤ 480
-0.4 ≤ WLOGP ≤ 5.6
40 ≤ MR ≤ 130
20 ≤ atoms ≤ 70

None
Veber?

Veber (GSK) filter: implemented from
Veber DF. et al. 2002 J. Med. Chem.
Rotatable bonds ≤ 10
TPSA ≤ 140

0.0
Egan?

Egan (Pharmacia) filter: implemented from
Egan WJ. et al. 2000 J. Med. Chem.
WLOGP ≤ 5.88
TPSA ≤ 131.6

0.0
Muegge?

Muegge (Bayer) filter: implemented from
Muegge I. et al. 2001 J. Med. Chem.
200 ≤ MW ≤ 600
-2 ≤ XLOGP ≤ 5
TPSA ≤ 150
Num. rings ≤ 7
Num. carbon > 4
Num. heteroatoms > 1
Num. rotatable bonds ≤ 15
H-bond acc. ≤ 10
H-bond don. ≤ 5

0.0
Bioavailability Score?

Abbott Bioavailability Score: Probability of F > 10% in rat
implemented from
Martin YC. 2005 J. Med. Chem.

0.55

Medicinal Chemistry

PAINS?

Pan Assay Interference Structures: implemented from
Baell JB. & Holloway GA. 2010 J. Med. Chem.

0.0 alert
Brenk?

Structural Alert: implemented from
Brenk R. et al. 2008 ChemMedChem

0.0 alert: heavy_metal
Leadlikeness?

Leadlikeness: implemented from
Teague SJ. 1999 Angew. Chem. Int. Ed.
250 ≤ MW ≤ 350
XLOGP ≤ 3.5
Num. rotatable bonds ≤ 7

No; 1 violation:MW<1.0
Synthetic accessibility?

Synthetic accessibility score: from 1 (very easy) to 10 (very difficult)
based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties,
trained on 12'782'590 molecules and tested on 40 external molecules (r2 = 0.94)

1.83

Application In Synthesis of [ 893620-44-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 893620-44-5 ]

[ 893620-44-5 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 1207293-52-4 ]
  • [ 893620-44-5 ]
YieldReaction ConditionsOperation in experiment
The crude product obtained is combined with 700 mg LiCl, 150 muL water and 50 mL DMSO and stirred for 3 h at 1000C. Then the reaction mixture is cooled to RT, combined with saturated saline solution and extracted repeatedly with EtOAc. The combined organic phases are dried, filtered and freed from the volatile constituents in vacuo. 20 mL acetic acid and 2 g iron powder are added to the remaining mixture which is then heated to 1000C until 5-fluoro-6-bromo-indolinone has formed. The reaction mixture is freed from the volatile constituents, combined with EtOAc, filtered and the product is isolated by normal phase chromatography.
  • 2
  • [ 893620-44-5 ]
  • [ 74-88-4 ]
  • [ 1581753-73-2 ]
YieldReaction ConditionsOperation in experiment
7.87 g d) 6-Bromo-5-fluoro-1 ,3-trimethylindolin-2-one To a suspension of NaH (5.04 g, 126 mmol) in tetrahydrofuran (105 ml) under an argon atmosphere was added <strong>[893620-44-5]6-bromo-5-fluoroindolin-2-one</strong> (7.24 g, 31.5 mmol) in portions. After gas evolution has ceased methyl iodide (17.9 g, 7.88 ml, 126 mmol) was added dropwise within 50 minutes by means of a syringe pump (exothermic reaction), keeping the temperature of the reaction mixture between 24C and 26C. The reaction mixture was kept at room temperature for 4 hours and then carefully quenched with aqueous ammonium chloride solution. The reaction mixture was diluted with tert-butyl methyl ether, water and saturated aqueous ammonium chloride solution. The aqueous phase was extracted with tert-butyl methyl ether, the combined organic phases were washed with saturated aqueous ammonium chloride and dried over sodium sulfate. The solvent was evaporated and the residue was triturated with heptane to give the title compound as light brown solid (7.87 g). 1H NMR (CDC13, 400 MHz): (ppm) = 7.02-6.97 (m, 2H), 3.19 (s, 3H), 1.36 (s, 6H).
7.87 g With sodium hydride; In tetrahydrofuran; at 20 - 26℃; for 4.83333h;Inert atmosphere; d) 6-Bromo-5-fluoro-1,3,3-trimethylindolin-2-one To a suspension of NaH (5.04 g, 126 mmol) in tetrahydrofuran (105 ml) 6-bromo-5- fluoroindolin-2-one (7.24 g, 31.5 mmol) was added portionwise under an argon atmosphere. After gas evolution had ceased methyl iodide (17.9 g, 7.88 ml, 126 mmol) was added dropwise within 50 minutes by means of a syringe pump (exothermic reaction), keeping the temperature of the reaction mixture between 24 C and 26 C. The reaction mixture was kept at roomtemperature for 4 hours and then carefully quenched with aqueous ammonium chloride solution. The reaction mixture was diluted with tert-butyl methyl ether, water and saturated aqueous ammonium chloride solution. The aqueous phase was extracted with tert-butyl methyl ether, the combined organic phases were washed with saturated aqueous ammonium chloride and dried over sodium sulfate. The solvent was evaporated and the residue was triturated with heptane to give the title compound as light brown solid (7.87 g).MS ESI (m/z): 272.1, 274.1 [(M+H)i.H NMR (CDC13, 400 MHz): (ppm) = 7.02-6.97 (m, 2H), 3.19 (s, 3H), 1.36 (s, 6H).
  • 3
  • [ 893620-44-5 ]
  • [ 74-88-4 ]
  • [ 1379313-54-8 ]
YieldReaction ConditionsOperation in experiment
3.6 g a) 6-Bromo-5-fluoro-3,3-dimethylindolin-2-one To a solution of potassium tert-butoxide (9.27 g, 82.6 mmol) in dry THF (50 ml) under icebath cooling was added <strong>[893620-44-5]6-bromo-5-fluoroindolin-2-one</strong> (example 20c, 3.8 g, 16.5 mmol) in portions, followed by copper (I) bromide-dimethyl sulfide complex (340 mg, 1.65 mmol). After cooling to 2C methyl iodide (4.92 g, 2.17 ml, 34.7 mmol) was added slowly over a period of 30 minutes. The reaction mixture was warmed to room temperature, stirred for 16 hours, then cooled to 0C and carefully quenched with saturated ammonium chloride solution. The mixture was diluted with tert-butyl methyl ether and water. The aqueous phase was extracted with tert-butyl methyl ether, the combined organic phases were dried over sodium sulfate, the solvent was evaporated and the residue purified by silica gel chromatography using ethyl acetate/ heptane as eluent and followed by trituration with diethyl ether. The title compound was obtained as yellow solid (3.6 g). MS ESI (m/z): 258.0/ 260.0 [(M+H)+]. 1H NMR (CDCI3, 400 MHz): (ppm) = 10.44 (bs, 1H), 7.48-7.45 (m, 1H), 7.05-7.04 (m, 1H), 1.25 (s, 6H).
  • 4
  • [ 345-24-4 ]
  • [ 108-59-8 ]
  • [ 893620-44-5 ]
YieldReaction ConditionsOperation in experiment
c) 6-Bromo-5-fluoroindolin-2-one A suspension of (4-bromo-5-fluoro-2-nitrophenyl)-acetic acid/ (2-bromo-5-fluoro-4-nitro- phenyl)-acetic acid (2.6: 1 mixture, 37.3 g, 134 mmol) and iron (30.0 g, 537 mmol) in acetic acid (671 ml) was heated to 100C for 7 hours and then cooled to room temperature. Remaining elemental iron was removed with a magnetic rod. Ice water (900 ml) was added to the reaction mixture. The precipitate was filtered off, washed four times with water and then suspended in an ice-cold aqueous solution of 25% HC1 (300 ml) and cone. HC1 (50 ml). After stirring for 10 minutes the precipitate was filtered off and washed four times with water. The precipitate was suspended in a mixture of 1 M aqueous Na2C03 (400 ml) solution and 0.1 M NaOH (100 ml) and stirred for 40 minutes. The precipitate was filtered off and washed four times with 0.1 M aqueous NaOH, three times with water and once with diisopropylether to give title compound as light grey solid (20.5 g). MS ESI (m/z): 228.0/ 230.0 [(M-H)"]. 1H NMR (DMSO-D6, 400 MHz): (ppm) = 10.47 (bs, 1H), 7.31-7.28 (m, 1H), 7.01-6.99 (m, 1H), 3.49 (s, 2H).
20.5 g a) 2-(4-Bromo-5-fluoro-2-nitro-phenyl)-malonic acid dimethyl ester/ 2-(2-Bromo-5-fluoro-4-nitro-phenyl)-malonic acid dimethyl ester A suspension of NaH (60 % in mineral oil, 20.2 g, 504 mmol) in dioxane (233 ml) was cooled to11 C. A solution of 1-bromo-2,4-difluoro-5-nitrobenzene (50 g, 26.5 ml, 210 mmol) anddimethyl malonate (33.3 g, 28.9 ml, 242 mmol) in dioxane (467 ml) was carefully added at 11 - 14 C within 45 minutes (gas evolution). After completion of the addition the reaction mixture was kept at 12 C for another hour and then warmed to room temperature. After 16 hours the reaction mixture was cooled to 10 C and 100 ml saturated aqueous ammonium chloride solutionwas added. The reaction mixture was diluted with tert-butyl methyl ether, water and saturated aqueous ammonium chloride solution. The aqueous phase was extracted with tert-butyl methyl ether, the combined organic phases were washed with saturated aqueous ammonium chloride solution and brine and dried over sodium sulfate. The solvent was evaporated and the residue purified by silica gel chromatography using ethyl acetate heptane as eluent. The title compoundswere obtained as yellow liquid (53.7 g) as a 2.6:1 mixture and used for the next reaction without further purification.. A mixture of 2-(4-bromo-5 -fluoro-2-nitro-phenyl)-malonic acid dimethyl ester 2-(2-bromo-5- fluoro-4-nitro-phenyl)-malonic acid dimethyl ester (2.6:1 mixture, 53.7 g, 153 mmol) and 6 Maqueous hydrochloric acid (767 ml) was heated to reflux for 7 hours and then cooled to 5 C. The precipitate was filtered, washed with water and with n-pentane and then coevaporated 3 times with toluene to give 25.9 g of a mixture of the title compounds as white solid. The mother liquor was extracted with ethyl acetate and the combined organic phases dried over sodium sulfate. The solvent was evaporated and the residue triturated with n-pentane and then coevaporated with toluene to give 11.42 g of a mixture of the title compounds as an off-white solid. This material was combined with the first crop to give a total of 37.32 g of the title compounds as a 2.6 :1 mixture which was used for the next reaction without further purification.A suspension of (4-bromo-5-fluoro-2-nitrophenyl)-acetic acid/ (2-bromo-5-fluoro-4-nitro- phenyl)-acetic acid (2.6:1 mixture, 37.3 g, 134 mmol) and iron (30.0 g, 537 mmol) in acetic acid (671 ml) was heated to 100 C for 7 hours and then cooled to room temperature. Remaining elemental iron was removed with a magnetic rod. Ice water (900 ml) was added to the reaction mixture. The precipitate was filtered off, washed four times with water and then suspended in anice-cold aqueous solution of 25 % HC1 (300 ml) and conc. HC1 (50 ml). After stuffing for 10 minutes the precipitate was filtered off and washed four times with water.The precipitate was suspended in a mixture of 1 M aqueous Na2CO3 (400 ml) solution and 0.1 M NaOH (100 ml) and stirred for 40 minutes. The precipitate was filtered off and washed four times with 0.1 M aqueous NaOH, three times with water and once with diisopropylether to givetitle compound as light grey solid (20.5 g). MS ESI (m/z): 228.0/ 230.0 [(M-H)i.1H NMR (DMSO-D6, 400 MHz): (ppm) = 10.47 (bs, 1H), 7.3 1-7.28 (m, 1H), 7.01-6.99 (m, 1H), 3.49 (s, 2H).
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 893620-44-5 ]

Fluorinated Building Blocks

Chemical Structure| 56341-41-4

A228764 [56341-41-4]

5-Fluoroindolin-2-one

Similarity: 0.83

Chemical Structure| 380431-78-7

A503631 [380431-78-7]

7-Bromo-5-fluoroindoline-2,3-dione

Similarity: 0.82

Chemical Structure| 56341-39-0

A235178 [56341-39-0]

6-Fluoroindolin-2-one

Similarity: 0.81

Chemical Structure| 71294-07-0

A372364 [71294-07-0]

5,6-Difluoroindolin-2-one

Similarity: 0.80

Chemical Structure| 1368323-85-6

A862691 [1368323-85-6]

5-Bromo-6-fluoroindoline

Similarity: 0.79

Bromides

Chemical Structure| 99365-40-9

A146590 [99365-40-9]

6-Bromoindolin-2-one

Similarity: 0.83

Chemical Structure| 380431-78-7

A503631 [380431-78-7]

7-Bromo-5-fluoroindoline-2,3-dione

Similarity: 0.82

Chemical Structure| 20870-78-4

A262692 [20870-78-4]

5-Bromoindolin-2-one

Similarity: 0.82

Chemical Structure| 90725-50-1

A177864 [90725-50-1]

6-Bromo-3-methylindolin-2-one

Similarity: 0.80

Chemical Structure| 557093-46-6

A198133 [557093-46-6]

5-Bromo-6-methylindolin-2-one

Similarity: 0.80

Amides

Chemical Structure| 99365-40-9

A146590 [99365-40-9]

6-Bromoindolin-2-one

Similarity: 0.83

Chemical Structure| 56341-41-4

A228764 [56341-41-4]

5-Fluoroindolin-2-one

Similarity: 0.83

Chemical Structure| 380431-78-7

A503631 [380431-78-7]

7-Bromo-5-fluoroindoline-2,3-dione

Similarity: 0.82

Chemical Structure| 20870-78-4

A262692 [20870-78-4]

5-Bromoindolin-2-one

Similarity: 0.82

Chemical Structure| 56341-39-0

A235178 [56341-39-0]

6-Fluoroindolin-2-one

Similarity: 0.81

Related Parent Nucleus of
[ 893620-44-5 ]

Indolines

Chemical Structure| 99365-40-9

A146590 [99365-40-9]

6-Bromoindolin-2-one

Similarity: 0.83

Chemical Structure| 56341-41-4

A228764 [56341-41-4]

5-Fluoroindolin-2-one

Similarity: 0.83

Chemical Structure| 380431-78-7

A503631 [380431-78-7]

7-Bromo-5-fluoroindoline-2,3-dione

Similarity: 0.82

Chemical Structure| 20870-78-4

A262692 [20870-78-4]

5-Bromoindolin-2-one

Similarity: 0.82

Chemical Structure| 56341-39-0

A235178 [56341-39-0]

6-Fluoroindolin-2-one

Similarity: 0.81