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Chemical Structure| 893420-19-4 Chemical Structure| 893420-19-4

Structure of 893420-19-4

Chemical Structure| 893420-19-4

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Product Details of [ 893420-19-4 ]

CAS No. :893420-19-4
Formula : C9H9BrClNO
M.W : 262.53
SMILES Code : O=C(N(C)C)C1=CC=C(Br)C=C1Cl
MDL No. :MFCD12756427

Safety of [ 893420-19-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 893420-19-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 893420-19-4 ]

[ 893420-19-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 845305-83-1 ]
  • [ 893420-19-4 ]
  • tert-butyl 4-((1-(3-chloro-4-(dimethylcarbamoyl)phenyl)piperidin-4-yl)oxy)piperidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
790 mg With palladium diacetate; sodium t-butanolate; DavePhos; In toluene; at 100℃;Inert atmosphere; Step 1 : tert-butyl 4-((l-(3-chloro-4-(dimethylcarbamoyl)phenyl)piperidin-4-yl)oxy)piperidine-l- carboxylate A mixture of tert-butyl 4-(piperi din-4-yloxy)piperi dine- 1-carboxy late ( 611.2mg, 2.15 mmol), 4- bromo-2-chloro-N,N-dimethylbenzamide (564 mg, 2.15 mmol), 2-dicyclohexylphosphino-2'- (N,N-dimethylamino)biphenyl (127 mg, 0.32 mmol), palladium (II) acetate ( 24.1 mg, 0.11 mmol), and sodium tert-butoxide (310mg, 3.22 mmol) in Toluene (10.7 ml) was degassed by bubbling with N2 and heated at 100C overnight. The reaction mixture was cooled to room temperature, filtered and then concentrated to dryness. The residue was purified by ISCO column chromatography (ISCO 80g prepacked , eluting with 0-100% EtOAc/Hexane) to give the title compound (790 mg). LCMS m/z (M+H): Calc'd 466.2, found 466.4.
 

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