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Chemical Structure| 89007-45-4 Chemical Structure| 89007-45-4

Structure of 89007-45-4

Chemical Structure| 89007-45-4

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Product Details of [ 89007-45-4 ]

CAS No. :89007-45-4
Formula : C10H11NS
M.W : 177.27
SMILES Code : CC(C1=CC=C(N=C=S)C=C1)C
MDL No. :MFCD00022060

Safety of [ 89007-45-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P322-P330-P332+P313-P337+P313-P340-P361-P362-P363-P403-P403+P233-P405-P501
Class:6.1
UN#:2810
Packing Group:

Application In Synthesis of [ 89007-45-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89007-45-4 ]

[ 89007-45-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 89007-45-4 ]
  • [ 6976-17-6 ]
  • 1-(3-carboxypropyl)-3-(4-isopropylphenyl)-1-methylthiourea [ No CAS ]
  • 2
  • [ 25475-67-6 ]
  • [ 89007-45-4 ]
  • N-(3H-[1,2,4]thiadiazolo[4,3-b]isoquinolin-3-ylidene)-4-isopropylaniline [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% With montmorillonite K10 Clay; In acetonitrile; at 20℃; for 2h; General procedure: A round bottom flask containing commercially available montmorillonite K10 (10 molpercent) was placed in an oven at 120-130°C for 30 minutes and then it was cooled to room temperature under nitrogen protection. To the activated montmorillonite K10 was added isothiocyanate (3.4 mmol) and <strong>[25475-67-6]3-aminoisoquinoline</strong> (3.4 mmol) followed by acetonitrile (2 mL) at room temperature. The resulting suspension was stirred at room temperature for 1-3 hour. When the reaction was completed (detected by TLC), ethyl acetate (30 mL) was added and the catalyst was filtered off to recover. The organic layer was washed with water (3×30 mL), and finally with half saturated brine, dried over anhydrous Na2SO4 and concentrated by rotary evaporator. Finally, the residue was purified by recrystallization from ethanol.
 

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