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Chemical Structure| 88915-26-8 Chemical Structure| 88915-26-8

Structure of 88915-26-8

Chemical Structure| 88915-26-8

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Product Details of [ 88915-26-8 ]

CAS No. :88915-26-8
Formula : C13H20N2
M.W : 204.31
SMILES Code : NCC1CCN(CC2=CC=CC=C2)CC1
MDL No. :MFCD04116211
InChI Key :KNUKUWNSGVICSX-UHFFFAOYSA-N
Pubchem ID :1514444

Safety of [ 88915-26-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338
Class:8
UN#:2735
Packing Group:

Application In Synthesis of [ 88915-26-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 88915-26-8 ]

[ 88915-26-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4442-53-9 ]
  • [ 88915-26-8 ]
  • [ 857650-87-4 ]
YieldReaction ConditionsOperation in experiment
63.1% Example 45 Preparation of intermediate N- [l- (benzyl)-4-piperidinyl] methyl]-1, 4- benzodioxane-5-carboxamide A suspension of 1, 4-benzodioxan-5-carboxylic acid (1.80 g, 10.0 mmol) and 1,1'- carbonyldiimidazole (1.78 g, 11.0 mmol) in CH3CN (100 ml) was stirred at room temperature for 2 h. 1-Benzyl-4-aminomethylpiperidine (from example 37) (2.04 g, 10.0 mmol) in CH3CN (10 ml) was added to the mixture and stirred overnight at room temperature. The reaction mixture was concentrated in vacuo, added EtOAc (200 ml) and washed with H2O (3 x 50 ml). The organic layer was dried over Na2SO4 and evaporated in vacuo to a solid material. The residue was separated with flash chromatography (Si02, EtOAc: MeOH, 1: 1) to leave the product as a white solid (2.31 g, 63.1 percent). 1H-NMR (200 MHz, CDCl3) : b 7.74 (dd, 1 H), 7.67 (t, 1 H), 7.34-7. 15 (m, 5 H), 7.03-6. 89 (m, 2 H), 4.43-4. 39 (m, 2 H), 4.33-4. 29 (m, 2 H), 3.52 (s, 2 H), 3.37 (t, 2 H), 2.93 (d, 2 H), 2.06-1. 93 (m, 2 H), 1.77-1. 50 (m, 3 H), 1.47-1. 28 (m, 2 H)
 

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