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Chemical Structure| 88805-67-8 Chemical Structure| 88805-67-8

Structure of 88805-67-8

Chemical Structure| 88805-67-8

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Product Details of [ 88805-67-8 ]

CAS No. :88805-67-8
Formula : C7H6ClN3
M.W : 167.60
SMILES Code : NC1=NNC2=C(Cl)C=CC=C12
MDL No. :MFCD07385618
InChI Key :HNISSRAYDSNHNN-UHFFFAOYSA-N
Pubchem ID :20135774

Safety of [ 88805-67-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 88805-67-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 88805-67-8 ]

[ 88805-67-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 88805-67-8 ]
  • [ 1260088-72-9 ]
  • 2-chloro-N-(7-chloro-1H-indazol-3-yl)-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
44% With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80.0℃; A 50 mL round-bottom flask was charged sequentially with <strong>[1260088-72-9]2,4-dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine</strong>7 (118.0 mg, 0.5386 mmol), 7-chloro-1H-indazol-3-amine (109.7 mg, 0.6545 mmol), N,N-dimethylformamide (3.0 mL) and N,N-diisopropylethylamine (0.25 mL, 1.4mmol). The resulting mixture was heated at 80 C overnight. The reaction mixture was then diluted withethyl acetate, washed with water (2x) and brine, dried over magnesium sulfate, filtered, and evaporated invacuo. The crude product was purified via flash chromatography on silica gel (12 g silica, solvent gradient:0-100% ethyl acetate in dichloromethane) to yield 82.5 mg (44%) of the title compound.
 

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