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Chemical Structure| 886371-79-5 Chemical Structure| 886371-79-5

Structure of 886371-79-5

Chemical Structure| 886371-79-5

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Product Details of [ 886371-79-5 ]

CAS No. :886371-79-5
Formula : C7H6FNO2
M.W : 155.13
SMILES Code : FC1=CC(=NC=C1)C(=O)OC
MDL No. :MFCD07374898
InChI Key :WVUMSXSSXWAGJM-UHFFFAOYSA-N
Pubchem ID :46311149

Safety of [ 886371-79-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 886371-79-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 886371-79-5 ]

[ 886371-79-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 886371-79-5 ]
  • [ 4522-35-4 ]
  • [ 1621525-15-2 ]
YieldReaction ConditionsOperation in experiment
INTERMEDIATE 23 Methyl 4-(3-iodo- lH-pyrazol- 1 -yl)picolinate To 3-iodo-lH-pyrazole (625 mg, 3.22 mmol) in DMSO (15 mL) at 0 C,was added sodium hydride (60% in mineral oil, 155 mg, 3.87 mmol). The reaction was stirred for 30 min before methyl 4-fluoropicolinate (500 mg, 3.22 mmol) was added and the reaction was stirred at 90 C for 4.5 h. The reaction mixture was quenched by the addition of water and the mixture was extracted with EtOAc. The combined organic extracts were dried over MgS04 and concentrated in vacuo. The crude mixture was purified by flash chromatography (ISCO Combiflash, 0-100%) EtOAc in hexanes) to afford methyl 4-(3-iodo-lH-pyrazol-l-yl)picolinate, as a colorless solid. LCMS calc. = 329.97; found = 329.88 (M+H)+.
 

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