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Chemical Structure| 884494-40-0 Chemical Structure| 884494-40-0

Structure of 884494-40-0

Chemical Structure| 884494-40-0

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Product Details of [ 884494-40-0 ]

CAS No. :884494-40-0
Formula : C10H12FNSi
M.W : 193.29
SMILES Code : C[Si](C#CC1=NC=C(F)C=C1)(C)C

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Application In Synthesis of [ 884494-40-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 884494-40-0 ]

[ 884494-40-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 884494-40-0 ]
  • [ 884494-34-2 ]
YieldReaction ConditionsOperation in experiment
80% With potassium hydroxide; In methanol; at 20℃; for 5h; Step 2: Preparation of 2-ethynyl-5-fluoropyridine A mixture of 5-fluoro-2-((trimethylsilyl)ethynyl)pyridine (3.5 g, 18.1 mmol) and potassium hydroxide (1.02 g, 18.1 mmol) in methanol (100 mL) was stirred at 20 C. for 5 h. The mixture was diluted with brine (100 mL), extracted with ethyl acetate (100 mL*2) and purified by column chromatography (silica, petroleum ether/ethyl acetate=20/1) to yield 2-ethynyl-5-fluoropyridine (1.75 g, 14.5 mmol, 80%) as a yellow oil. LCMS (ESI) m/z: 122.0 [M+H]+.
 

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