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Chemical Structure| 881681-01-2 Chemical Structure| 881681-01-2

Structure of Vonoprazan Fumarate
CAS No.: 881681-01-2

Chemical Structure| 881681-01-2

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TAK-438, a potassium proton pump inhibitor, can reversibly inhibit H+/K+ ATPase with IC50 of 17 nM and does not affect Na+/K+ ATPase. It also controls gastric acid secretion.

Synonyms: TAK-438

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Product Citations

Roberto Grosso ; Elena Benito ; Ana I. Carbajo-Gordillo ; Manuel Jesús Díaz ; M. Gracia García-Martín ; M.-Violante de-Paz

Abstract: The escalating challenges of Helicobacter pylori-induced gastric complications, driven by rising antibiotic resistance and persistent cancer risks, underscore the demand for innovative therapeutic strategies. This study addresses this urgency through the development of tailored semi-interpenetrating polymer networks (semi-IPN) serving as gastroretentive matrices for amoxicillin (AMOX). They are biodegradable, absorb significant volume of simulated gastric fluid (swelling index > 360 %) and exhibit superporous microstructures, remarkable mucoadhesion, and buoyancy. The investigation includes assessment at pH 1.2 for comparative analysis with prior studies and, notably, at pH 5.0, reflecting the acidic environment in H. pylori-infected stomachs. The semiIPN demonstrated gel-like structures, maintaining integrity throughout the 24-hour controlled release study, and disintegrating upon completing their intended function. Evaluated in gastroretentive drug delivery system performance, AMOX release at pH 1.2 and pH 5.0 over 24 h (10 %-100 %) employed experimental design methodology, elucidating dominant release mechanisms. Their mucoadhesive, buoyant, three-dimensional scaffold stability, and gastric biodegradability make them ideal for accommodating substantial AMOX quantities. Furthermore, exploring the inclusion of the potassium-competitive acid blocker (P-CAB) vonoprazan (VONO) in AMOX-loaded formulations shows promise for precise and effective drug delivery. This innovative approach has the potential to combat H. pylori infections, thereby preventing the gastric cancer induced by this pathogen.

Keywords: Semi-IPN ; Guar gum ; Superporous matrix ; Helicobacter pylori ; Gastric cancer ; Mucoadhesive polymers ; Amoxicillin ; Vonoprazan ; Korsmeyer-Peppas model

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Product Details of Vonoprazan Fumarate

CAS No. :881681-01-2
Formula : C21H20FN3O6S
M.W : 461.46
SMILES Code : O=S(N1C=C(CNC)C=C1C2=CC=CC=C2F)(C3=CC=CN=C3)=O.O=C(O)/C=C/C(O)=O
Synonyms :
TAK-438
MDL No. :MFCD18633280
InChI Key :ROGSHYHKHPCCJW-WLHGVMLRSA-N
Pubchem ID :45375887

Safety of Vonoprazan Fumarate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01568398 Gastric Ulcer|Duodenal Ulcer PHASE3 COMPLETED 2025-08-13 Funabashi-shi, Chiba, Japan|No... More >>da-shi, Chiba, Japan|Fukuoka-shi, Fukuoka, Japan|Annaka-shi, Gunma, Japan|Hiroshima-shi, Hiroshima, Japan|Hakodate-shi, Hokkaido, Japan|Kitahiroshima-shi, Hokkaido, Japan|Sapporo-shi, Hokkaido, Japan|Yubari-gun, Hokkaido, Japan|Kanazawa-shi, Ishikawa, Japan|Sanuki-shi, Kagawa, Japan|Sendai-shi, Miyagi, Japan|Nagasaki-shi, Nagasaki, Japan|Sasebo-shi, Nagasaki, Japan|Fuchu-shi, Tokyo, Japan|Katsushika-ku, Tokyo, Japan|Meguro-ku, Tokyo, Japan|Minato-ku, Tokyo, Japan|Nakano-ku, Tokyo, Japan Less <<
NCT01568385 Gastric Ulcer|Duodenal Ulcer PHASE3 COMPLETED 2025-09-13 Funabashi-shi, Chiba, Japan|No... More >>da-shi, Chiba, Japan|Fukuoka-shi, Fukuoka, Japan|Annaka-shi, Gunma, Japan|Hiroshima-shi, Hiroshima, Japan|Hakodate-shi, Hokkaido, Japan|Kitahiroshima-shi, Hokkaido, Japan|Sapporo-shi, Hokkaido, Japan|Yubari-gun, Hokkaido, Japan|Kanazawa-shi, Ishikawa, Japan|Sanuki-shi, Kagawa, Japan|Yashiro-shi, Kumamoto, Japan|Nagasaki-shi, Nagasaki, Japan|Sasebo-shi, Nagasaki, Japan|Fuchu-shi, Tokyo, Japan|Katsushika-ku, Tokyo, Japan|Meguro-ku, Tokyo, Japan|Nakano-ku, Tokyo, Japan Less <<
NCT03085836 Healthy Participants PHASE1 COMPLETED 2017-08-17 Zhongshan Hospital Fudan Unive... More >>rsity, Shanghai, 200032, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.84mL

2.17mL

1.08mL

21.67mL

4.33mL

2.17mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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