Home Cart Sign in  
Chemical Structure| 88157-42-0 Chemical Structure| 88157-42-0

Structure of 88157-42-0

Chemical Structure| 88157-42-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 88157-42-0 ]

CAS No. :88157-42-0
Formula : C6H10O3
M.W : 130.14
SMILES Code : COC(=O)C1(CO)CC1
MDL No. :MFCD16036399
InChI Key :YLNAXTUVFOXHTI-UHFFFAOYSA-N
Pubchem ID :22934721

Safety of [ 88157-42-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 88157-42-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 88157-42-0 ]

[ 88157-42-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 6914-71-2 ]
  • [ 88157-42-0 ]
YieldReaction ConditionsOperation in experiment
60% With lithium tri-(tert-butoxy)aluminum hydride; In tetrahydrofuran; at 65℃; To a solution of dimethyl cyclopropane-1,1-dicarboxylate (6.32 g, 40 mmol) inanhydrous THF (120 mL) was added a solution of lithium tri-tert-butoxyaluminum hydride inTHF (IM, 88 mL) and the mixture was stirred at 65 °C overnight. To the mixture were addedH20 (4 mL) and 15percent aq NaOH (4 mL). The mixture was dried over drying agent and filtered.The filtrate was concentrated under reduced pressure to afford methyl 1-(hydroxymethyl)cyclopropane-1-carboxylate as a yellow oil (3.11 g, 60percent).
  • 2
  • [ 88157-42-0 ]
  • [ 164513-38-6 ]
  • [ 1383001-33-9 ]
YieldReaction ConditionsOperation in experiment
With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 70℃; for 4h; Example 100[0357] [Formula 129][0358] 1) In tetrahydrofuran (26 mL) was dissolved <strong>[164513-38-6]5-bromo-4-methylpyridin-2-ol</strong> (1.3 g), methyl l-(hydroxymethyl)cyclopropanecarboxylate (1.08 g) and triphenylphosphine (2.72 g), and 40% diethyl azodicarboxylate-toluene solution (4.72 mL) was added dropwise to the solution at 0C. The mixture was stirred at 70C for 4 hours. The reaction mixture was cooled to room temperature, water and ethyl acetate were added to the mixture, and the organic layer was washed with a saturated brine and dried over anhydrous sodium sulfate. After concentrating the mixture under reduced pressure, the obtained residue was purified by silica gel column chromatography (n-hexane: ethyl acetate=99: l to 99:5) to obtain methyl l-[(5-bromo-4-methylpyridin-2-yl)oxy]- methyljcyclopropanecarboxylate (2.08 g).MS (m/z): 300/302 [M+H]+
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 88157-42-0 ]

Aliphatic Cyclic Hydrocarbons

Chemical Structure| 113020-21-6

A221325 [113020-21-6]

1-(Methoxycarbonyl)cyclopropanecarboxylic acid

Similarity: 0.97

Chemical Structure| 6914-71-2

A500494 [6914-71-2]

1,1-Cyclopropanedicarboxylic acid dimethyl ester

Similarity: 0.97

Chemical Structure| 3697-68-5

A122295 [3697-68-5]

Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate

Similarity: 0.93

Chemical Structure| 67567-55-9

A369629 [67567-55-9]

1-(Methoxymethyl)cyclopropanecarboxylic acid

Similarity: 0.93

Chemical Structure| 1559-02-0

A144505 [1559-02-0]

Diethyl 1,1-cyclopropanedicarboxylate

Similarity: 0.90

Alcohols

Chemical Structure| 3697-68-5

A122295 [3697-68-5]

Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate

Similarity: 0.93

Chemical Structure| 56970-75-3

A216676 [56970-75-3]

Methyl 2-(hydroxymethyl)butanoate

Similarity: 0.93

Esters

Chemical Structure| 113020-21-6

A221325 [113020-21-6]

1-(Methoxycarbonyl)cyclopropanecarboxylic acid

Similarity: 0.97

Chemical Structure| 6914-71-2

A500494 [6914-71-2]

1,1-Cyclopropanedicarboxylic acid dimethyl ester

Similarity: 0.97

Chemical Structure| 3697-68-5

A122295 [3697-68-5]

Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate

Similarity: 0.93

Chemical Structure| 39520-25-7

A762149 [39520-25-7]

Dimethyl 2-(tert-butyl)malonate

Similarity: 0.93

Chemical Structure| 39994-40-6

A419948 [39994-40-6]

Trimethyl propane-1,2,2-tricarboxylate

Similarity: 0.93