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Chemical Structure| 879275-35-1 Chemical Structure| 879275-35-1

Structure of 879275-35-1

Chemical Structure| 879275-35-1

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Product Details of [ 879275-35-1 ]

CAS No. :879275-35-1
Formula : C19H28N2O4
M.W : 348.44
SMILES Code : O=C(N1C[C@@H](CNC(OCC2=CC=CC=C2)=O)CCC1)OC(C)(C)C

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Application In Synthesis of [ 879275-35-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 879275-35-1 ]

[ 879275-35-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 501-53-1 ]
  • [ 140645-23-4 ]
  • [ 879275-35-1 ]
YieldReaction ConditionsOperation in experiment
74% With triethylamine; In dichloromethane; at 0 - 20℃; for 16h; (R)-tert-Butyl 3-(aminomethyl)piperidine-l-carboxylate (1.00 g, 4.67 mmol) wasdissolved in 14 mL anhydrous CH2CI2 under an N2 atmosphere and cooled to 0 C. Triethylamine (1.30 mL, 945 mg, 9.34 mmol) was added followed by the dropwise addition of benzyl chloroformate (0.99 mL, 1.20 g, 7.00 mmol). After 16 h, the reaction was complete. The mixture was partitioned between H2O and CH2CI2, and separated, and the aqueous layer was extracted twice with CH2CI2. The organic layers were combined, dried over Na2S04, filtered, and concentrated to a light yellow oil. Purification via silica gel chromatography using 97% CH2Cl2/3% MeOH gave, benzyl ((i?)-l-(tert-butoxycarbonyl)piperidin-3-yl)methylcarbamate as a clear colorless oil (1.2 g, 74%). LC/MS: m/z 349.5 (M+H)+ at 3.21 min (10%-99% CH3CN (0.035% TFA)/H20 (0.05% TFA)).
 

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