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Chemical Structure| 874-27-1 Chemical Structure| 874-27-1

Structure of 874-27-1

Chemical Structure| 874-27-1

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Product Details of [ 874-27-1 ]

CAS No. :874-27-1
Formula : C8H7ClO
M.W : 154.59
SMILES Code : O=CC1=CC=CC(Cl)=C1C
MDL No. :MFCD11047716
Boiling Point : No data available
InChI Key :WMDHVKYUOKHNQK-UHFFFAOYSA-N
Pubchem ID :13162662

Safety of [ 874-27-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 874-27-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 874-27-1 ]

[ 874-27-1 ] Synthesis Path-Downstream   1~35

  • 1
  • [ 141-82-2 ]
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  • [ 879-51-6 ]
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  • [ 75-17-2 ]
  • [ 87-60-5 ]
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  • 3
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  • [ 90369-75-8 ]
  • 4
  • [ 54454-12-5 ]
  • [ 874-27-1 ]
YieldReaction ConditionsOperation in experiment
69% With hydrogenchloride; In dichloromethane; A. 3-Chloro-2-methylbenzaldehyde To 3-chloro-2-methylbenzonitrile (5 g, 33 mmol) in dichloromethane (150 mL) at -78 C. was added DiBAL (1M in dichloromethane, 41 mL). The reaction mixture was stirred at -78 C. for 2 h then quenched with methanol. The mixture was warmed to 0 C and HCl (10%) was added. The ice-water bath was removed and the mixture was stirred at room temperature for 10 min. The two phases were separated and aqueous phase was extracted with dichloromethane. Combined dichloromethane was washed with brine, dried over sodium sulfate and concentrated. Column chromatography (5% ethyl acetate/hexane) gave 3-chloro-2-methylbenzaldehyde (3.5 g, 69%). 1H NMR (300 MHz, CDCl3) delta 2.64 (s, 3H), 7.21-7.26 (m, 1H), 7.50-7.53(m, 1H), 7.63-7.66 (m, 1H), 10.20 (s, 1H)
  • 5
  • [ 587-04-2 ]
  • [ 74-88-4 ]
  • [ 874-27-1 ]
  • 6
  • [ 118-69-4 ]
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  • 8
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  • [ 90369-76-9 ]
  • 16
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  • [ 90369-87-2 ]
  • 19
  • [ 874-27-1 ]
  • [ 90388-41-3 ]
  • 28
  • [ 874-27-1 ]
  • [ 90133-70-3 ]
  • 32
  • [ 874-27-1 ]
  • [ 942-17-6 ]
  • 33
  • [ 874-27-1 ]
  • 5-Chlor-4-methyl-indan [ No CAS ]
  • 34
  • [ 874-27-1 ]
  • [ 942-18-7 ]
  • 35
  • [ 874-27-1 ]
  • [ 879-50-5 ]
 

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Technical Information

• Alkyl Halide Occurrence • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Julia-Kocienski Olefination • Kinetics of Alkyl Halides • Knoevenagel Condensation • Kumada Cross-Coupling Reaction • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reformatsky Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Stetter Reaction • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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