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Chemical Structure| 871700-32-2 Chemical Structure| 871700-32-2

Structure of 871700-32-2

Chemical Structure| 871700-32-2

3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate

CAS No.: 871700-32-2

4.5 *For Research Use Only !

Cat. No.: A868776 Purity: 98%

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Product Details of [ 871700-32-2 ]

CAS No. :871700-32-2
Formula : C25H21FIN3O6S
M.W : 637.42
SMILES Code : O=S(C1=CC=C(C)C=C1)(OC(C(C(N2C3CC3)=O)=C4N(C5=CC=C(I)C=C5F)C2=O)=C(C)C(N4C)=O)=O
MDL No. :MFCD18207186

Safety of [ 871700-32-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 871700-32-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 871700-32-2 ]

[ 871700-32-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 871700-24-2 ]
  • [ 98-59-9 ]
  • [ 871700-32-2 ]
YieldReaction ConditionsOperation in experiment
91% With trimethylamine hydrochloride; triethylamine; In acetonitrile; at 0 - 20℃; for 4.0h; Under a nitrogen atmosphere, to 3-cyclopropyl-l-(2-fluoro- 4-iodo-phenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3- d] pyrimidine-2,4,7-trione 55 (23.9 g) was added acetonitrile (167 ml), and the mixture was stirred under ice-cooling. Triethylamine (11.0 ml) and trimethylamine hydrochloride (2.37 g) were added, and a solution of p-toluenesulfonyl chloride 11 (12.3 g) in acetonitrile (72.0 ml) was added dropwise. The mixture was stirred under ice-cooling for 1 hr, and stirred at room temperature for 3 hrs. Methanol (239 ml) was added, and the mixture was stirred at room temperature for 1 hr. The crystals were collected by filtration and dried to give p-toluenesulfonic acid 3-cyclopropyl-1-(2-fluoro-4-iodo-phenyl)-6,8-dimethyl-2,4,7- trioxo-1,2,3,4,7,8-hexahydro-pyrido[2,3-d]pyrimidin-5-yl ester 77 (28.7 g, yield 91%) as colorless crystals.
 

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