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Chemical Structure| 87154-95-8 Chemical Structure| 87154-95-8

Structure of 87154-95-8

Chemical Structure| 87154-95-8

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Product Details of [ 87154-95-8 ]

CAS No. :87154-95-8
Formula : C13H17N3O
M.W : 231.29
SMILES Code : O=C1NC2=C(C=C(N3CCNCC3)C=C2)CC1
MDL No. :MFCD08458432

Safety of [ 87154-95-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 87154-95-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 87154-95-8 ]

[ 87154-95-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 21560-29-2 ]
  • [ 87154-95-8 ]
  • 6-[4-(6,7-dimethoxyisoquinolin-1-yl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; chloroform; EXAMPLE 5 <strong>[21560-29-2]1-Chloro-6,7-dimethoxyisoquinoline</strong> (0.63 g) and 6-(1-piperazinyl)-3,4-dihydro-2(1H)-quinolinone (1.30 g) were mixed at 200 C. for 1.5 hours under stirring. The mixture was dissolved in a mixture of chloroform and methanol (10:1 V/V) and subjected to a column chromatography on silica gel (eluent:methanol in chloroform, 0-2% V/V). The fractions containing the object compound were combined and concentrated and the residue was triturated with diisopropyl ether to give 6-[4-(6,7-dimethoxyisoquinolin-1-yl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone (0.44 g). mp: 235-240 C. IR (Nujol): 1670, 1620 cm-1 NMR (DMSO-d6, delta): 2.2-3.7 (12H, m), 3.96 (6H, s), 6.7-7.1 (3H, m), 7.2-7.6 (3H, m), 8.05 (1H, d, J=7 Hz), 9.88 (1H, br s)
 

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