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Chemical Structure| 869224-62-4 Chemical Structure| 869224-62-4

Structure of 869224-62-4

Chemical Structure| 869224-62-4

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Product Details of [ 869224-62-4 ]

CAS No. :869224-62-4
Formula : C9H17NO
M.W : 155.24
SMILES Code : OC1CCN(C2CCC2)CC1
MDL No. :MFCD11878581
InChI Key :DFNHWMSTHVIRFR-UHFFFAOYSA-N
Pubchem ID :58155416

Safety of [ 869224-62-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312-P330-P501

Application In Synthesis of [ 869224-62-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 869224-62-4 ]

[ 869224-62-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 869224-62-4 ]
  • [ 1151665-15-4 ]
  • [ 1190440-42-6 ]
YieldReaction ConditionsOperation in experiment
55% With potassium tert-butylate; In 1,4-dioxane; at 115℃; for 0.666667h;Inert atmosphere; Microwave irradiation; A mixture of tert-butyl 2-chloro-7,8-dihydro-l,6-naphthyridine-6(5H)-carboxylate ( 0.59 g, 2.20 mmol), l-cyclobutylpiperidin-4-ol (0.52 g, 3.30 mmol) and potassium tert-butoxide (0.62 g, 5.50 mmol) in dioxane (20 volumes) was heated at 115C for 40 min in a CEM microwave reactor (150W) under N2 (g) atmosphere. The reaction mixture was diluted with EtOAc, <n="80"/>washed with brine, dried (Na2SO4), filtered and concentrated at reduced pressure. The residue (0.9 g) was purified by FCC (SiO2, eluting with DCM/MeOH/NH3, 90:10:1) to give the title compound (0.47 g, 55%).LCMS data: Calculated MH+ (387); Found 100% (M+) m/z 387, Rt = 5.78 min. 1H NMR (250 MHz, CHLOROFORM-J) delta ppm 1.38 - 2.15 (21 H, m) 2.47 - 2.81 (5 H, m) 3.63 (2 H, t, J=5.86 Hz) 4.40 (2 H, s) 4.97 (1 H, br. s.) 6.47 (1 H, d, J=8.38 Hz) 7.06 (1 H, d, J=8.38 Hz).
 

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