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Chemical Structure| 867062-95-1
Chemical Structure| 867062-95-1
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Product Details of [ 867062-95-1 ]

CAS No. :867062-95-1 MDL No. :MFCD06656471
Formula : C24H29NO7 Boiling Point : -
Linear Structure Formula :- InChI Key :CHIDDYZONKDHLG-UHFFFAOYSA-N
M.W : 443.49 Pubchem ID :2756185
Synonyms :

Safety of [ 867062-95-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 867062-95-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 867062-95-1 ]
  • Downstream synthetic route of [ 867062-95-1 ]

[ 867062-95-1 ] Synthesis Path-Upstream   1~7

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YieldReaction ConditionsOperation in experiment
80%
Stage #1: With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 0.333333 h;
Stage #2: at 0 - 20℃;
In the sixth step, NH2PEG3-CH2CH2COOH.HCL (33.5 g, 0.13 mol)Was dissolved in 80 mL of tetrahydrofuran and 120 mL of water,NaHCO3 (27.3 g, 0.33 mol) was added and stirred at room temperature for 20 minutes.Cool to 0 ° C and Fmoc-OSu (43.9 g, 0.13 mol) was added in portions.After the addition, the mixture was stirred at room temperature overnight, separated the next day, and the aqueous phase was extracted with ethyl acetate.The aqueous phase was acidified to pH = 3 with 1 mol / L hydrochloric acid and extracted three times with ethyl acetate. The organic phases were combined,Washed twice with saturated brine,Dried and evaporated to dryness of crude Fmoc-NH-PEG3-CH2CH2COOH (46.04 g yield 80percent),20 g of the crude product was dissolved in 50 ml of ethyl acetate under heating and cooled to natural crystals,Suction filter solid 16 grams,The yield was 80percentHPLC detection content of 99.1percent.
Reference: [1] Patent: CN104774161, 2017, B, . Location in patent: Paragraph 0019; 0020; 0026
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Reference: [1] Organic and Biomolecular Chemistry, 2015, vol. 13, # 1, p. 81 - 97
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Reference: [1] Organic and Biomolecular Chemistry, 2015, vol. 13, # 1, p. 81 - 97
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Reference: [1] Organic and Biomolecular Chemistry, 2015, vol. 13, # 1, p. 81 - 97
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  • [ 867062-95-1 ]
Reference: [1] Organic and Biomolecular Chemistry, 2015, vol. 13, # 1, p. 81 - 97
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  • [ 867062-95-1 ]
Reference: [1] Organic and Biomolecular Chemistry, 2015, vol. 13, # 1, p. 81 - 97
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Reference: [1] Patent: CN104774161, 2017, B,
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