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Chemical Structure| 863317-29-7 Chemical Structure| 863317-29-7

Structure of 863317-29-7

Chemical Structure| 863317-29-7

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Product Details of [ 863317-29-7 ]

CAS No. :863317-29-7
Formula : C8H9BrN2O
M.W : 229.07
SMILES Code : O=C(NN)CC1=CC=CC(Br)=C1
MDL No. :MFCD16159318

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Application In Synthesis of [ 863317-29-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 863317-29-7 ]

[ 863317-29-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 943541-20-6 ]
  • [ 863317-29-7 ]
  • [ 1201930-17-7 ]
YieldReaction ConditionsOperation in experiment
In butan-1-ol; at 130℃; for 18h; 1.4 A suspension of 3.89 g (20.0 mmol) of <strong>[943541-20-6]3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine</strong> and 4.58 g (20.0 mmol) of (3-bromophenyl)acetohydrazide in 40 ml of 1-butanol is heated at 130 C. for 18 hours. The reaction mixture is cooled and partitioned between ethyl acetate and saturated sodium hydrogencarbonate solution. The organic phase is dried over sodium sulfate and evaporated. The residue is chromatographed on a silica-gel column with dichloromethane /tert-butyl methyl ether /methanol as eluent: 3-(3-bromobenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo-[4,3-b]pyridazine as beige crystals; ESI 369, 371.
 

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