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Structure of 862081-37-6

Chemical Structure| 862081-37-6

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Product Details of [ 862081-37-6 ]

CAS No. :862081-37-6
Formula : C14H17BO4
M.W : 260.09
SMILES Code : O=C1OCC2=CC(B3OC(C)(C)C(C)(C)O3)=CC=C12
MDL No. :MFCD18251723
InChI Key :OPVQSJKJDSJOJD-UHFFFAOYSA-N
Pubchem ID :58074623

Safety of [ 862081-37-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 862081-37-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 862081-37-6 ]

[ 862081-37-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 862081-37-6 ]
  • [ 1227573-02-5 ]
  • [ 1308670-19-0 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In water; N,N-dimethyl-formamide; at 100℃; for 1h;Inert atmosphere; Step 2: 3-fluoro-5-(1-oxo-1 ,3-dihydro-isobenzofuran-5-yl)-pyridine-4-carbaldehyde (35b) To 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3H-isobenzofuran-1-one (210 mg, 0.809 mmol) in DMF (4 mL) was added <strong>[1227573-02-5]3-bromo-5-fluoro-pyridine-4-carbaldehyde</strong> (150 mg, 0.735 mmol) and 2M aqueous sodium carbonate (0.735 mL, 1.471 mmol). The reaction mixture was flushed and evacuated with N2 twice followed by the addition of PdCI2(dppf).CH2CI2 adduct (30.0 mg, 0.037 mmol). The reaction mixture was stirred at 100 °C for 1 hour. The reaction was cooled to room temperature, diluted with ethyl acetate and washed with water twice. The organic layer was separated, dried over sodium sulfate and concentrated in vacuo to afford 3-fluoro-5-(1 -oxo-1 ,3-dihydro-isobenzofuran-5-yl)-pyridine-4-carbaldehyde, which was taken into the next step without further purification.
  • 2
  • [ 862081-37-6 ]
  • [ 1227573-02-5 ]
  • [ 1308669-44-4 ]
 

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Related Functional Groups of
[ 862081-37-6 ]

Organoborons

Chemical Structure| 862081-38-7

A150092 [862081-38-7]

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A543338 [849677-21-0]

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A658384 [2157414-14-5]

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Esters

Chemical Structure| 862081-38-7

A150092 [862081-38-7]

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A543338 [849677-21-0]

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Chemical Structure| 2157414-14-5

A658384 [2157414-14-5]

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Chemical Structure| 525362-07-6

A287638 [525362-07-6]

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Related Parent Nucleus of
[ 862081-37-6 ]

Benzofurans

Chemical Structure| 862081-38-7

A150092 [862081-38-7]

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isobenzofuran-1(3H)-one

Similarity: 1.00

Chemical Structure| 849677-21-0

A543338 [849677-21-0]

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isobenzofuran-1,3-dione

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