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Chemical Structure| 86-38-4 Chemical Structure| 86-38-4

Structure of 86-38-4

Chemical Structure| 86-38-4

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Product Details of [ 86-38-4 ]

CAS No. :86-38-4
Formula : C14H9Cl2NO
M.W : 278.13
SMILES Code : COC1=CC2=C(Cl)C3=CC=C(Cl)C=C3N=C2C=C1
MDL No. :MFCD00005028

Safety of [ 86-38-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 86-38-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 86-38-4 ]

[ 86-38-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 29608-05-7 ]
  • [ 86-38-4 ]
  • 6-chloro-2-methoxy-N-(4-((piperidin-1-yl)methyl)phenyl)acridin-9-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: A previously described method [19] was followed for the syntheses of 1-5, 7, 8, 10 and 20. Briefly, equimolar quantities of the amine and the acridine/quinoline were dissolved in ethanol, 2 drops of conc. HCl were added and the mixture refluxed for ca 24 h. On cooling, NaOH (1 M) or ammonia solution (25%) was added, followed by dichloromethane to extract the product. Alternatively, if the product precipitated out of solution on alkalinization, it was removed by filtration and purified by column chromatography.
  • 2
  • [ 86-38-4 ]
  • [ 129999-60-6 ]
  • 6-chloro-9-[2-(4'-hydroxypiperidin-1-yl)ethyl]amino-2-methoxyacridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
42% With phenol; at 90℃; for 5h; General procedure: A mixture of 6,9-dichloro-2-methoxyacridine (1.8 mmol), theappropriate amine (1.8 mmol) and phenol (1.13 g) was heated at90 C for 5 h. After cooling, the mixture was treated with 6 MNaOHtill strong alkalinity and extracted with Et2O. After removing thesolvent, the residue was purified by CC.In the case of 12 the reaction mixture was rinsed up with waterand washed thoroughly with H2O, obtaining the final compound ashydrochloride salt.Compounds 2-8 were obtained by washing the reaction mixturein the order, with a boiling solution of 2 N NaOH and thenwith water in order to remove the excess of phenol, affording asolid residue that was chromatographed on silica gel, eluting withthe indicated solvent.
  • 3
  • [ 21252-69-7 ]
  • [ 86-38-4 ]
  • 1-(6-chloro-2-methoxyacridin-9-yl)-3-octylimidazolium chloride [ No CAS ]
 

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