Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 85803-49-2 Chemical Structure| 85803-49-2

Structure of 85803-49-2

Chemical Structure| 85803-49-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 85803-49-2 ]

CAS No. :85803-49-2
Formula : C8H12N2S
M.W : 168.26
SMILES Code : S1C=CC=C1C2CNCCN2
MDL No. :MFCD06245415
InChI Key :BFVCDPJJFUPNAQ-UHFFFAOYSA-N
Pubchem ID :2771726

Safety of [ 85803-49-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P301+P310
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 85803-49-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 85803-49-2 ]

[ 85803-49-2 ] Synthesis Path-Downstream   1~21

  • 1
  • [ 541-41-3 ]
  • [ 85803-49-2 ]
  • [ 85803-50-5 ]
  • 2
  • 5-Thiophen-2-yl-2,3-dihydro-pyrazine [ No CAS ]
  • [ 85803-49-2 ]
  • 3
  • [ 51445-63-7 ]
  • [ 85803-49-2 ]
  • 4
  • [ 85803-49-2 ]
  • [ 85803-57-2 ]
  • 5
  • [ 85803-49-2 ]
  • [ 85803-54-9 ]
  • 6
  • [ 85803-49-2 ]
  • [ 85803-52-7 ]
  • 7
  • [ 85803-49-2 ]
  • [ 85803-58-3 ]
  • 8
  • [ 85803-49-2 ]
  • [ 85803-60-7 ]
  • 9
  • [ 85803-49-2 ]
  • [ 85803-55-0 ]
YieldReaction ConditionsOperation in experiment
A solution of 8.2 g of ethylenediamine in 250 ml of ethanol was added to a solution of 17.64 g of the above aldehyde in 250 ml of ethanol at 0 C. This mixture was stirred at room temperature for 1.5 hours, recooled to 0 C. and 9.6 g of sodium borohydride was added. This mixture was stirred overnight, quenched with water and the ethanol removed. The residue was extracted with dichloromethane, washed with water, dried and evaporated. The residue was crystallized with ether-hexane, giving 12 g of 2-(2-thienyl)piperazine.
  • 11
  • [ 86393-33-1 ]
  • [ 85803-49-2 ]
  • 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-methyl-3-(thien-3-yl)-1-piperazinyl]-3-quinolinecarboxylic acid [ No CAS ]
  • 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(thien-3-yl)-1-piperazinyl]-3-quinolinecarboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; EXAMPLE 66 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-methyl-3-(3-thienyl)-1-piperazinyl]-3-quinolinecarboxylic acid A mixture of 1.124 g of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 2.688 g of 3-thienylpiperazine and 12 ml of pyridine was reacted as described in Example 60, giving 900 mg of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(3-thienyl)-1-piperazinyl]-3-quinolinecarboxylic acid. A 207 mg portion of the above compound was then reacted as described in Example 55, giving 150 mg of the desired product, mp 230 C.
  • 12
  • [ 132669-51-3 ]
  • [ 85803-49-2 ]
  • (RS)-3-ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-[3-(thien-2-yl)-1-piperazinyl]-1,4-dihydrobenzo[b][1,8]naphthyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
(RS)-3-Ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-[3-(2-thienyl)-1-piperazinyl]-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 39, but starting with 3-ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (1.59 g) and (RS)-<strong>[85803-49-2]2-(2-thienyl)piperazine</strong> (1.02 g). (RS)-3-Ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-[3-(2-thienyl)-1-piperazinyl ]-1,4-dihydrobenzo[b][1,8]naphthyridine (2.25 g) is obtained in the form of a yellow solid, m.p. 228 C.
  • 13
  • [ 132669-21-7 ]
  • [ 85803-49-2 ]
  • [ 137684-64-1 ]
YieldReaction ConditionsOperation in experiment
(RS)-1-Cyclopropyl-3-ethoxycarbonyl-7-fluoro-4-oxo-8-[3-(2-thienyl)-1-piperazinyl]-1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 39, but starting with 1-cyclopropyl-7,8-difluoro-3-ethoxycarbonyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (1.7 g) and (RS)-<strong>[85803-49-2]2-(2-thienyl)piperazine</strong> (1 g). (RS)-1-Cyclopropyl-3-ethoxycarbonyl-7-fluoro-4-oxo-8-[3-(2-thienyl)-1-piperazinyl]-1,4-dihydrobenzo[b][1,8]naphthyridine (2.2 g) is obtained in the form of a yellow solid, m.p. 210-212 C.
  • 14
  • [ 132669-30-8 ]
  • [ 85803-49-2 ]
  • (RS)-3-ethoxycarbonyl-7,9-difluoro-1-methyl-4-oxo-8-[3-(thien-2-yl)-1-piperazinyl]-1,4-dihydrobenzo[b][1,8]naphthyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
(RS)-3-Ethoxycarbonyl-7,9-difluoro-1-methyl-4-oxo-8-[3-(2-thienyl)-1-piperazinyl]1,4-dihydrobenzo[b][1,8]naphthyridine was prepared under the conditions of Example 39, but starting with 3-ethoxycarbonyl-7,8,9-trifluoro-1-methyl-4-oxo-1,4-dihydrobenzo [b][1,8]naphthyridine (1.68 g) and (RS)-<strong>[85803-49-2]2-(2-thienyl)piperazine</strong> (1.01 g). (RS)-3-Ethoxycarbonyl-7,9-difluoro-1-methyl-4-oxo-8-[3-(2-thienyl)-1-piperazinyl]-1,4-dihydrobenzo[b][1,8]naphthyridine (1.68 g) is thereby obtained in the form of a yellow solid, m.p. 220 C.
  • 15
  • 1,4-diazobicyclo-[2,2,2]-octane [ No CAS ]
  • [ 94695-52-0 ]
  • [ 85803-49-2 ]
  • 1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-[3-(thien-2-yl)-1-piperazinyl]-3-quinolinecarboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; water; dimethyl sulfoxide; STR27 2.8 g (0.01 mole) of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (Example A) are heated to 140 C. together with 1.8 g (0.011 mole) of <strong>[85803-49-2]2-(2-thienyl)piperazine</strong> and 2.2 g (0.02 mole) of 1,4-diazobicyclo[2.2.2]octane in 6 ml of DMSO for 2 hours. The mixture is concentrated under high vacuum, the residue is stirred with 20 ml of water, and the precipitate is filtered off with suction and boiled in 20 ml of methanol. 2.4 g (56% of theory) of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-[3-(2-thienyl)-1-piperazinyl]-3-quinolinecarboxylic acid of melting point 252-254 C. (with decomposition) are obtained. The melting point remains unchanged after recrystallization from glycol monomethyl ether.
  • 16
  • [ 1172227-73-4 ]
  • [ 85803-49-2 ]
YieldReaction ConditionsOperation in experiment
With sodium borohydrid; ethylenediamine; In ethanol; water; PREPARATION 1 2-(2-Thienyl)Piperazine A solution of ethylenediamine (4.1 g, 0.068 mol) in ethanol (25 ml) is added dropwise to a solution of 2-thienylglyoxal hydrate [prepared by the procedure of F. Kipnis and J. Ornfelt, J. Amer. Chem. Soc. 68, 2734 (1946)] (10.0 g, 0.063 mol) in ethanol (250 ml) at 0 C. under an atmosphere of dry nitrogen. The cooling bath is removed and the reaction mixture stirred for an additional 1.5 h. Sodium borohydride (4.5 g, 0.126 mol) is added all at once, and a cooling bath used to control the exothermic reaction. Stirring is continued for an additional 18 h. Water (25 ml) is added, and the ethanol removed under reduced pressure. The remaining aqueous solution is extracted with methylene chloride (3*100 ml) and the extracts dried with potassium carbonate. Removal of the solvent under reduced pressure gives 2-(2-thienyl)piperazine as an off-white solid. An analytical sample is obtained by addition of an ethereal solution of the base to an ethereal solution of oxalic acid dihydrate.
  • 17
  • C19H16N4O2 [ No CAS ]
  • [ 85803-49-2 ]
  • C46H44N10O4S [ No CAS ]
  • 18
  • C20H18N4O2 [ No CAS ]
  • [ 85803-49-2 ]
  • C48H48N10O4S [ No CAS ]
  • 19
  • C19H15ClN4O2 [ No CAS ]
  • [ 85803-49-2 ]
  • C46H42Cl2N10O4S [ No CAS ]
  • 20
  • [ 68077-26-9 ]
  • [ 85803-49-2 ]
  • 1-Ethyl-6-fluoro-1,4-dihydro-7-[4-methyl-3-(thien-2-yl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid [ No CAS ]
  • 21
  • [ 68077-26-9 ]
  • [ 85803-49-2 ]
  • 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(thien-2-yl)-1-piperazinyl]-3-quinolinecarboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; In acetic acid; A mixture of 504 mg of the above piperazine, 269 mg of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 10 ml of pyridine was refluxed under argon for 24 hours, then cooled and evaporated under reduced pressure. The residue was triturated with ether, the solid collected, dissolved in 40% acetic acid and neutralized with 1N sodium hydroxide. The solid was collected, washed with methanol, ether and dried, giving 110 mg of the desired product, mp 232-234 C.
 

Historical Records

Categories