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Chemical Structure| 857653-95-3 Chemical Structure| 857653-95-3

Structure of 857653-95-3

Chemical Structure| 857653-95-3

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Product Details of [ 857653-95-3 ]

CAS No. :857653-95-3
Formula : C9H9N3O4S
M.W : 255.25
SMILES Code : CS(=O)(OCC1=NC(C2=CC=NC=C2)=NO1)=O
MDL No. :MFCD31714207

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Application In Synthesis of [ 857653-95-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 857653-95-3 ]

[ 857653-95-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 857653-95-3 ]
  • [ 134464-79-2 ]
  • 4-(3-pyridin-4-yl-[1,2,4]oxadiazol-5-ylmethylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium tert-butylate; In tetrahydrofuran; for 1.66667h; Example 131: 4- (3-Pyridin-4-yl- [1, 2,4] oxadiazol-5-ylmethylsulfanyl) piperidine-1-carboxylic acid tert-butyl ester t-BuOK (92mg, 83µmol) and methanesulfonic acid 3-pyridin-4-yl- [1, 2,4] oxadiazol-5- ylmethyl ester (Preparation 12,150mg, 588µmol) were added to a stirred solution of 4- mercaptopiperidine-l-carboxylic acid tert-butyl ester (191mg, 881µmol) in anhydrous THF (lOml). After 10min, the reaction mixture was diluted with Et2O, before being washed with NaHCO3 and brine. The organic layer was dried (MgSO4), filtered, and concentrated, then the residue was purified by column chromatography (IH-EtOAc, 3: 2) to afford the title compound: RT = 3. 77min ; mlz (ES) = 377.2 [M+H] +.
 

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