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Chemical Structure| 856900-26-0 Chemical Structure| 856900-26-0

Structure of 856900-26-0

Chemical Structure| 856900-26-0

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Product Details of [ 856900-26-0 ]

CAS No. :856900-26-0
Formula : C13H20N2O2
M.W : 236.31
SMILES Code : O=C(N1C2CC(C#N)CC1CC2)OC(C)(C)C
MDL No. :MFCD12068414

Safety of [ 856900-26-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 856900-26-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 856900-26-0 ]

[ 856900-26-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 661463-17-8 ]
  • [ 856900-26-0 ]
  • 3-(6-fluoroquinolin-4-carbonyl)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% Under nitrogen protection and -70 C,Dissolve in 20 mL of THF containing <strong>[661463-17-8]4-bromo-6-fluoroquinoline</strong> (1.4 g, 6.2 mmol)n-Butyllithium (1.6 M in n-hexane solution, 3.9 mL, 6.2 mmol) was added dropwise to the solution.The reaction mixture is stirred at -70 CAfter 30 min, a solution of 3-cyano-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (1.4 g, 5.6 mmol) in 5 mL THF was added dropwise.The system was stirred at 70 C for 2 h.Pour into 100mL of saturated ammonium chloride solution,Then extract with EA (50mL x 3),The organic phase is washed with saturated brine.The anhydrous Na2SO4 was sufficiently dried.Concentration under reduced pressure and column chromatography (DCM:MeOH = 30:1)Purification afforded 1.1 g (yield: 46%) of title compound.It is a yellow solid.
  • 2
  • [ 25602-68-0 ]
  • [ 856900-26-0 ]
 

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