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Chemical Structure| 854750-32-6 Chemical Structure| 854750-32-6

Structure of 854750-32-6

Chemical Structure| 854750-32-6

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Product Details of [ 854750-32-6 ]

CAS No. :854750-32-6
Formula : C9H19N
M.W : 141.25
SMILES Code : CCC(C1CCCCC1)N
MDL No. :MFCD12154070

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Application In Synthesis of [ 854750-32-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 854750-32-6 ]

[ 854750-32-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 885521-46-0 ]
  • [ 854750-32-6 ]
  • [ 1430472-97-1 ]
YieldReaction ConditionsOperation in experiment
38% With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0℃; for 1h; The mixture of 1-cyclohexylpropan-l -amine (380 mg, 2.69 mmol), 3- iodo-lH-indazole-5-carboxylic acid (774.9 mg, 2.69 mmol), DIPEA (1.33 mL, 8.07 mmols) in DMF (8 mL) was cooled down to 0C and added TBTU (864 mg, 2.69 mmol). After stirring at 0 C for 1 h, H20 was added followed by EtOAc. The organic layer was separated and washed with H20 (3x),brine, dried over Na2S04 and concentrated under reduced pressure to provide the title compound as a light yellow solid (418 mg, 38 % yield). ? NMR (400 MHz, CDCli) delta ppm 10.65 (s, 1H), 7.92 (m, 2H), 7.54 (d, J = 8.8 Hz, 1H), 5.89 (d, J = 4.1 Hz, 1H), 4.02 (m, 1H), 1.86-1.67 (m, 6H), 1.56-1.44 (m, 2H), 1.31-1.06 (m, 4H), 0.99 (t, J= 8.2 Hz, 3H); MS ESI [M + H]+412.3, calcd for [C17H22I 3O+ H]+ 412.09.
 

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