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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 85475-01-0 Chemical Structure| 85475-01-0
Chemical Structure| 85475-01-0
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Product Details of Hydroxy-PEG1-methylamine

CAS No. :85475-01-0
Formula : C5H13NO2
M.W : 119.16
SMILES Code : CNCCOCCO
MDL No. :MFCD12783671

Safety of Hydroxy-PEG1-methylamine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H335-H314-H227
Precautionary Statements:P210-P260-P264-P270-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378-P403+P233-P403+P235-P405-P501
Class:8
UN#:2735
Packing Group:

Application In Synthesis of Hydroxy-PEG1-methylamine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 85475-01-0 ]

[ 85475-01-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 593-51-1 ]
  • [ 118591-58-5 ]
  • [ 85475-01-0 ]
YieldReaction ConditionsOperation in experiment
52% With potassium carbonate; In 1,4-dioxane; at 50℃; Compound 1-3 (5.1 g, 19.6 mmol) was dissolved in 1,4-dioxane (50 mL), followed by addition of methylamine hydrochloride 1-4 (13.4 g, 196 mmol), and potassium carbonate (13.8 g, 100 mmol) was added under stirring in batches, followed by stirring the reaction overnight under conditions of 50° C. and a closed reaction system, TLC monitoring showed that the starting material 1-3 was completely reacted. The solvent was removed under reduced pressure to obtain a concentrated residue. The concentrated residue was dispensed with dichloromethane (20 mL), an appropriate amount of silica gel was added and the sample was stirred, spin-dried under reduced pressure and directly placed on a silica gel column for column chromatographic purification, with an eluent (dichloromethane:methanol=20/1-5/1) to obtain the target product 1-5 (1.2 g, 52percent) as a pale yellow oil, LC-MS: m/z=120[M+H]+.
  • 2
  • [ 118591-58-5 ]
  • [ 74-89-5 ]
  • [ 85475-01-0 ]
YieldReaction ConditionsOperation in experiment
99% at 85℃; for 16h;Inert atmosphere; A mixture of 2-(2-hydroxyethoxy)ethyl 4-methylbenzenesulfonate (3 g, 11.52 mmol, 1 eq) in methanamine (11.93 g, 115.25 mmol, 10 eq) was degassed and purged with nitrogen for 3 times, and then the mixture was stirred at 85 C for 16 hours under nitrogen. The reaction mixture was concentrated under reduced pressure to give a residue. Compound 2-[2- (methylamino)ethoxy] ethanol (1.37 g, 11.50 mmol, 99% yield) was obtained as a yellow oil. 'H- NMR (400MHz, CDCb) d 3.72 - 3.47 (m, 8H), 2.67 - 2.63 (m, 3H).
at 70℃; for 12h;Sealed tube; A solution of 2-(2-hydroxyethoxy)ethyl 4-methylbenzenesulfonate (2.50 g, 9.60 mmol, 1 eq) and methanamine (40.0 mL, 1.00 eq) in sealed tube was stirred at 70 C. for 12 hours. Analysis by TLC indicated 2-(2-hydroxyethoxy)ethyl 4-methylbenzenesulfonate was consumed completely. The reaction mixture was concentrated under reduced pressure to remove methanamine (40.0 mL, 1.00 eq) to give 2-[2-(methylamino)ethoxy]ethanol (1.10 g, crude) as a yellow oil.
 

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