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Chemical Structure| 852339-65-2 Chemical Structure| 852339-65-2

Structure of 852339-65-2

Chemical Structure| 852339-65-2

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Product Details of [ 852339-65-2 ]

CAS No. :852339-65-2
Formula : C15H25NO5
M.W : 299.36
SMILES Code : O=C(OC(C)(C)C)N(C1)CCCC1(CC=O)C(OCC)=O
MDL No. :MFCD24470249

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Application In Synthesis of [ 852339-65-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 852339-65-2 ]

[ 852339-65-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 852339-65-2 ]
  • [ 15205-15-9 ]
  • tert-butyl 2-(2-chloro-6-fluorobenzyl)-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; acetic acid; In N,N-dimethyl-formamide; at 20℃; for 1.5h; Example 5 tert-butyl 2-(2-chloro-6-fluorobenzyl)-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate: To a solution of the compound prepared in Example 3 (346 mg, 1.03 mmol) in N,N-dimethylformamide (4 mL) were added <strong>[15205-15-9]2-chloro-6-fluorobenzylamine</strong> (166 mg, 1.04 mmol), acetic acid (1 mL) and sodium triacetoxyborohydride (328 mg, 1.55 mmol). The mixture was stirred for 1.5 hours at room temperature. To the reaction mixture was added a saturated aqueous solution of sodium bicarbonate, and then the mixture was extracted with ethyl acetate (twice). The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over an anhydrous magnesium sulfate and then concentrated. The residue was purified by column chromatography on silica gel (hexane: ethyl acetate = 2: 1) to give the title compound (177 mg) having the following physical data. TLC: Rf 0.37 (hexane: ethyl acetate = 2: 1); NMR: delta 1.69 (m, 15H), 2.94 (m, 4H), 3.97 (m, 2H), 4.67 (m, 2H), 7.01 (m, 1H), 7.22 (m, 2H).
 

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