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Chemical Structure| 852062-16-9 Chemical Structure| 852062-16-9

Structure of 852062-16-9

Chemical Structure| 852062-16-9

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Product Details of [ 852062-16-9 ]

CAS No. :852062-16-9
Formula : C7H4F4N2O
M.W : 208.11
SMILES Code : O=C(C1=NC=C(C(F)(F)F)C=C1F)N
MDL No. :MFCD16038708

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Application In Synthesis of [ 852062-16-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 852062-16-9 ]

[ 852062-16-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 852062-16-9 ]
  • [ 852062-17-0 ]
YieldReaction ConditionsOperation in experiment
20% With potassium hydroxide; water; bromine; at 0 - 20℃; for 122.0h; Description 118; 3-Fluoro-5-trifluoromethylpvridin-2-amine; Bromine (630 Ill, 1.3 mmol) was added to a solution of KOH (3.3 g, 58 mmol) in water (30 ml) cooled at 0C. The resulting yellow solution was stirred for 5 minutes, then Description 117 (2 g, 9.6 mmol) was added in portions over 2 hours and the reaction mixture stirred at room temperature for 5 days. The mixture was then extracted 3 times with diethyl ether and the combined organic extracts dried over Na2SO4, filtered, and evaporated to give a solid (330 mg, 20%). 1H NMR (400 MHz, CDCI3) 5.07 (2 H, s), 7.40 (1 H, dd, J10.4 and 1.6), 8.14 (1 H, s).
 

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