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CAS No. : | 84689-37-2 | MDL No. : | MFCD19690055 |
Formula : | C11H11NO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | AEMWYMNWYXZDHH-UHFFFAOYSA-N |
M.W : | 173.21 | Pubchem ID : | 12820990 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | UN#: | |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate In methanol at 60℃; for 48h; Inert atmosphere; Sealed tube; Overall yield = 58 %; Overall yield = 100 mg; | General procedure for the synthesis of isoquinolines General procedure: Vinyl acetate (922μL, 10.0mmol) was added to a solution of the acetylated oxime (1mmol) in MeOH (0.5mL, 2M) with CsOAc (58mg, 0.3mmol) and [Cp*RhCl2]2 (6mg, 0.01mmol) in a septum-topped vial under nitrogen. The reaction vials were sealed and heated to 60°C for 48h. The crude reaction mixture was loaded on to a 5g SCX column that was subsequently washed with MeOH (2×25mL). The product eluted with the secondary wash using 0.7M NH3 in MeOH (2×25mL) to give the clean product (>90% purity). Products containing impurities were purified using flash silica chromatography. |