843646-72-0|2-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide| Ambeed

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CAS No. :	843646-72-0
Formula :	C₁₄H₂₀BNO₃
M.W :	261.13
SMILES Code :	O=C(N)CC1=CC=CC(B2OC(C)(C)C(C)(C)O2)=C1
MDL No. :	MFCD08669540

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P264-P302+P352-P304+P340-P305+P351+P338-P332+P313-P337+P313

Yield	Reaction Conditions	Operation in experiment
78%	With potassium acetate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 1,1'-bis(diphenylphosphino)ferrocene; In 1,4-dioxane; at 90℃; for 18h;Inert atmosphere;	In a Schlenk tube, a mixture of <strong>[60312-83-6]2-(3-bromophenyl)acetamide</strong> (1.0 g, 4.67 mmol), bis(pinacolato)diboron (2.37 g, 9.34 mmol) and potassium acetate (1.38 g, 14 mmol) was dissolved in dioxane (40ml). The mixture was purged (vacuum-argon three times) and [1,1-Bis(diphenylphosphino)ferrocene]dichloropalladium(II)dichloromethane complex (0.19 g, 0.23 mmol) and 1,1'-bis(diphenylphospheno)ferrocene (0.13 g, 0.23 mmol) were added. The mixture was purged again (vacuum-argon three times) and stirred at 90 C for 18 h. The suspension was filtered off and the filtrated diluted with water and extracted three times with ethyl acetate. The combined organic layers were washed with water and brine, and dried over anhydrous sodium sulphate. Solvent was removed in vacuum and the residue was purified by the SP1 automated purification system to give 0.95 g (3.64 mmol) of the desired compound. Yield = 78% HPLC/MS (15 min) retention time 6.28 min. LRMS: m/z 262 (M+1)
65%	With potassium acetate;palladium diacetate; In DMF (N,N-dimethyl-formamide); at 80℃; for 12.3333h;	A mixture of 2- (3-BROMO-PHENYL)-ACETAMIDE (600 mg, 2.8 MMOL), potassium acetate (63 mg, 0.28 mmol, 0.1 eq), bis (pinacolato) diboron (783 mg, 3.08 mmol, 1.1 eq), in anhydrous DMF was degassed under N2 for 10 min. Then palladium acetate (824 mg, 8.41 mmol, 3 eq) was added, and the mixture degassed an additional 10 min. The reaction was then heated to 80 C for 12 h. The reaction mixture was then poured into ethyl acetate and water. Extracted with ethyl acetate (3 x 20 mL). The combined organic layer was dried with sodium sulfate, filtered through celite pad and concentrated in vacuo. The crude material was used directly to the next step. Yield : (473 mg, 65%). LC-MS (MH+ = 262).

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P222	Do not allow contact with air.
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P230	Keep wetted
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P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
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P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
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Disposal
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P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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CAS No.: 843646-72-0

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CAS No.: 843646-72-0

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[ 843646-72-0 ] Synthesis Path-Downstream 1~2

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed