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Chemical Structure| 84131-04-4 Chemical Structure| 84131-04-4

Structure of 84131-04-4

Chemical Structure| 84131-04-4

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Product Details of [ 84131-04-4 ]

CAS No. :84131-04-4
Formula : C20H26O6S
M.W : 394.48
SMILES Code : O=S(C1=CC=C(C)C=C1)(OCCOCCOCCOCC2=CC=CC=C2)=O
MDL No. :MFCD31555345
InChI Key :SULYUXLJHONROP-UHFFFAOYSA-N
Pubchem ID :12853231

Safety of [ 84131-04-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 84131-04-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 84131-04-4 ]

[ 84131-04-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 84131-04-4 ]
  • [ 3386-18-3 ]
  • 2
  • [ 84131-04-4 ]
  • [ 100858-32-0 ]
  • (S)-3-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}pyrrolidine-1-carboxylic acid benzyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
69.6% To a solution of (S)-3-hydroxy-pyrrolidine- l -carboxylic acid benzyl ester (3.5 g, 15 mmol, 1.2 eq) in 60 mL of anhydrous tetrahydrofuran, NaH (60% in oil, 800 mg, 20 mmol) was added and the solution was stirred at room temperature for thirty minutes. Toluene-4-sulfonic acid 2-[2-benzyolxy-ethoxy)-ethoxy] ethyl ester (5 g, 13 mmol leq) was then added. The mixture was heated at 50 C overnight. LC-MS analysis revealed the formation of a new product. Saturated aqueous ammonium chloride solution ( 10 mL) was added to the mixture and the aqueous layer was extracted with ether (4 x 15 mL). The combined organic layers were washed with saturated sodium bicarbonate solution (4 x10 mL), brine (4 x 10 mL), dried over magnesium sulfate and concentrated in vacuo. The residue was purified by column chromatography on silica gel using a gradient of hexane/ethyl acetate (10-60 % ethyl acetate) to give (S)-3-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}- pyrrolidine-l -carboxylic acid benzyl ester (4 g, 69.6%) as light brown oil.
 

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