83345-11-3|N-(4-(2-Hydroxyethyl)phenyl)acetamide| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 83345-11-3 ] Purity: 95% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 83345-11-3 ]

CAS No. :	83345-11-3
Formula :	C₁₀H₁₃NO₂
M.W :	179.22
SMILES Code :	CC(NC1=CC=C(CCO)C=C1)=O
MDL No. :	MFCD01536093
Boiling Point :	No data available
InChI Key :	VYEJXTZQKRHBHH-UHFFFAOYSA-N
Pubchem ID :	3295905

Safety of [ 83345-11-3 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P261-P280-P305+P351+P338

Application In Synthesis of [ 83345-11-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 83345-11-3 ]

[ 83345-11-3 ] Synthesis Path-Downstream 1~21

1
[ 83345-11-3 ]
acetic acid-[4-(2-hydroxy-ethyl)-2-nitro-anilide] [ No CAS ]

References: [1]Bulletin de la Societe Chimique de France,1933,vol. <4> 53,p. 330,332.

2
[ 108-24-7 ]
[ 104-10-9 ]
[ 83345-11-3 ]

Yield	Reaction Conditions	Operation in experiment
39.2%	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 4.0h;	. To a stirred solution of 2-(4- aminophenyl)ethan-l-ol (500 mg, 3.64 mmol) and DIPEA (942.1 mg, 7.29 mmol) in DCM (10 mL) was added Ac20 (372.1 mg, 3.64 mmol) dropwise at room temperature. The resulting mixture was stirred for 4 h at room temperature, then was concentrated and the residue was purified on silica gel column with EA/PE (1/1) to afford N-[4-(2- hydroxyethyl)phenyl] acetamide (256 mg, 39.2%) as an off-white solid. ES-MS (m/z): [M+l]+ = 180.

References: [1]Patent: WO2020/14332,2020,A1 .Location in patent: Paragraph 00241.
[2]Bulletin de la Societe Chimique de France,1933,vol. <4> 53,p. 330,332.
[3]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 3183 - 3187.
[4]RSC Advances,2014,vol. 4,p. 3883 - 3886.

3
[ 83345-11-3 ]
[ 166272-81-7 ]
3-[2-(4-acetylamino-phenyl)-ethoxy]-4-chloro-benzoic acid methyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 3290 - 3312.

4
[ 83345-11-3 ]
[ 214822-96-5 ]
3-[2-(4-acetylamino-phenyl)-ethoxy]-4-fluoro-benzoic acid methyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 3290 - 3312.

Yield	Reaction Conditions	Operation in experiment
		(c) 4'-(2-Hydroxyethyl)acetanilide A solution of the product from step (b) (55.3 g) in methanol (250 ml) and 1N aqu. NaOH (500 ml) was stirred at room temperature for 1 hour. The methanol was evaporated in vacuo and the remaining aqueous solution adjusted to pH 4 (2N aqu. HCl), saturated with NaCl, and extracted with ethyl acetate (*3). The combined extracts were washed with water and brine, dried over MgSO4 and evaporated in vacuo to give a brown oil which was flash chromatographed through a silica column using ethyl acetate and then crystallized from ethyl acetate to give the desired product (51.7 g).

6
[ 83345-11-3 ]
[ 1085309-04-1 ]