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Chemical Structure| 832714-08-6 Chemical Structure| 832714-08-6

Structure of 832714-08-6

Chemical Structure| 832714-08-6

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Product Details of [ 832714-08-6 ]

CAS No. :832714-08-6
Formula : C12H9ClN4O2S
M.W : 308.74
SMILES Code : O=S(C1=CC=C(N2N=CC3=C(Cl)N=CN=C32)C=C1)(C)=O

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Application In Synthesis of [ 832714-08-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 832714-08-6 ]

[ 832714-08-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 832714-08-6 ]
  • [ 134464-79-2 ]
  • [ 832716-87-7 ]
YieldReaction ConditionsOperation in experiment
66% With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20℃; for 1h; 4-CHLORO-1-(4-METHANESULFONYL-PHENYL)-LH-PYRAZOLO [3, 4-d] pyrimidine (1. 23 mmol, 250 mg), 4- MERCAPTO-PIPERIDINE-1-CARBOXYLIC acid tert-butyl ester (1. 23 mmol, 268 mg) and potassium carbonate (1. 4 mmol, 203 mg) were dissolved in DMF (10 ML) and stirred for 60 minutes at room temperature. Its progress was followed by thin layer chromatography and LCMS. The reaction mixture was quenched with water followed by an extraction with ethylacetate. Removal of organic solvents in vacuo and purification by column chromatography provided compound A102 as a white solid (264 mg, 66%) O TH NMR (400 MHz, CDC13) B (ppm) : 8. 83 (s, 1H) ; 8. 61 (d, 2H) ; 8. 24 (s, 1H) ; 8. 11 (d, 2H) ; 4. 42 (h, 1H) ; 4. 00 (M, 2H) ; 3. 20 (m, 2H) ; 3. 15 (s, 3H) ; 2. 19 (M, 2H) ; 1. 77 (M, 2H) ; 1. 46 (s, 9H).. LCMS (ESI), M/Z 490. 3 (MH+, 100%)
 

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