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Chemical Structure| 827042-63-7 Chemical Structure| 827042-63-7

Structure of 827042-63-7

Chemical Structure| 827042-63-7

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Product Details of [ 827042-63-7 ]

CAS No. :827042-63-7
Formula : C9H7ClN2O2
M.W : 210.62
SMILES Code : O=C(C1=NC2=CC(Cl)=C(C)C=C2N1)O

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Application In Synthesis of [ 827042-63-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 827042-63-7 ]

[ 827042-63-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 102877-78-1 ]
  • [ 827042-63-7 ]
  • N-[4-(pyridine-4-yloxy)phenyl]-5-chloro-6-methyl-1H-benzimidazole-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
26% With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20℃; 0.064 mmol of benzimidazolecarboxylic acid 4H was dissolved in DMF together with 0. 064 mmol of the amine 5A, A solution of TBTU (0. 096 MMOL) in DMF, HOBT (0. 026 MMOL) in DMF and 0. 32 mmol of DIPEA were added successively, and the mixture was stirred overnight at room temperature. The reaction mixture was diluted with water, and the resulting precipitate was filtered off with suction and washed with water. The resulting solid was digested a number of times with ethyl acetate, and the combined filtrates were evaporated. Yield : 26%, brown solid
 

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