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Chemical Structure| 82622-46-6 Chemical Structure| 82622-46-6

Structure of 82622-46-6

Chemical Structure| 82622-46-6

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Product Details of [ 82622-46-6 ]

CAS No. :82622-46-6
Formula : C10H11ClF3NO
M.W : 253.65
SMILES Code : FC(C1=CC=CC=C1OC2CNC2)(F)F.[H]Cl
MDL No. :MFCD11849028

Safety of [ 82622-46-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 82622-46-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 82622-46-6 ]

[ 82622-46-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 82622-46-6 ]
  • [ 65202-50-8 ]
  • methyl 6-{3-[2-(trifluoromethyl)phenoxy]azetidin-1-yl}pyridazine-3-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In tert-butyl alcohol; for 48h;Heating / reflux; Step 3: Methyl 6-{3-r2-(trifluoromethyl)phenoxy1azetidin-l-yl)pyridazine-3-carboxylate; Into a flame-dried 100 mL round-bottom flask equipped with a magnetic stirring bar and under N2 was added <strong>[65202-50-8]methyl 6-chloropyridazine-3-carboxylate</strong> (935 mg, 5.42 mmol), 3- [2-(trifluoromethyl)phenoxy]azetidine hydrochloride (1.25 g, 4.93 mmol) and potassium carbonate (2.04 g, 14.8 mmol) in tert-butanol (20 mL). The suspension was heated to reflux for 2 d. The reaction mixture was concentrated and purified by column chromatography through silica gel to give the indicated product as an off-white solid.1H NMR (CDCl3, 400 MHz): delta 7.94 (IH, d, J= 9.5 Hz), 7.64 (IH, d, J= 8.0 Hz), 7.53 (IH, t, J = 8.0 Hz), 7.11 (IH, t, J= 8.0 Hz), 6.76 (IH, d, J= 8.0 Hz), 6.60 (IH, d, J= 9.5 Hz), 5.27 (IH, tt, J = 6.5, 4.0 Hz), 4.70 (2H, dd, J= 10.0, 6.5 Hz), 4.38 (2H, dd, J= 10.0, 4.0 Hz), 4.01 (3H, s). MS (ESI, Q+) m/z 354 (M + 1).
 

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