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Chemical Structure| 82278-36-2 Chemical Structure| 82278-36-2

Structure of 82278-36-2

Chemical Structure| 82278-36-2

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Product Details of [ 82278-36-2 ]

CAS No. :82278-36-2
Formula : C15H22F3N3
M.W : 301.35
SMILES Code : NCCCCN1CCN(C2=CC=CC(C(F)(F)F)=C2)CC1
MDL No. :MFCD10686864

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Application In Synthesis of [ 82278-36-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 82278-36-2 ]

[ 82278-36-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 42260-39-9 ]
  • [ 82278-36-2 ]
  • 2-{4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]butyl}amino-4-phenylpyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dmap; at 300 - 350℃; for 0.05h; Step c: Preparation of 2-{4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]butyl}amino-4-phenylpyridine In a test tube, 0.38 g (2.0 mmol) of <strong>[42260-39-9]2-chloro-4-phenylpyridine</strong>, 0.6 g (2.0 mmol) of 4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]butylamine and a spatula tipful of 4-dimethylaminopyridine are heated to approximately 300-350° C. for 3 minutes. The mixture is diluted with ethyl acetate and chromatographed on silica gel (eluent: dichloromethane/ethanol 90/10). After concentration of the elution fractions, the product crystallises. After comminution in diethyl oxide, filtration and drying, 80 mg of 2-{4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]butyl}amino-4-phenylpyridine are obtained in the form of a white solid. Melting point: 120° C. (tube) 1H NMR (CDCl3): 8.1 (doublet, 1H); 7.65 to 7.55 (unresolved peaks, 2H); 7.5 to 7.25 (unresolved peaks, 4H); 7.2 to 7.0 (unresolved peaks, 3H); 6.8 (doublet, 1H); 6.55 (singlet, 1H); 4.8 (wide triplet, 1H); 3.35 (multiplet, 2H); 3.35 to 3.15 (unresolved peaks, 4H); 2.7 to 2.55 (unresolved peaks, 4H); 2.45 (triplet, 2H); 1.85 to 1.65 (unresolved peaks, 4H)
  • 2
  • [ 62124-43-0 ]
  • [ 82278-36-2 ]
  • 2-{4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]butyl}amino-5-phenyloxazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
12% With triethylamine; In tetrahydrofuran; at 0℃; Step b: Preparation of 2-{4-[4-(3-trifluoromethylphenyl)piperazin-1-yl]butyl}-amino-5-phenyloxazole A solution of 35 mg (0.2 mmol) of <strong>[62124-43-0]2-chloro-5-phenyloxazole</strong> in 0.5 mL of tetrahydrofuran is added, at 0° C., to a solution of 62 mg (0.2 mmol) of 4-[4-(3-trifluoromethylphenyl)piperazine-1-yl]butylamine (Example 3, step b) and 20 mg (0.2 mmol) of triethylamine in 0.2 mL of tetrahydrofuran. The mixture is stirred overnight under argon. After concentration under a vacuum, the product is purified by silica gel chromatography (eluent: dichloromethane/methanol 97/3). White solid Yield: 12percent Melting point: 151° C. 1H NMR (CDCl3): 7.45 to 7.3 (unresolved peaks, 4H); 7.2 to 7.05 (unresolved peaks, 5H); 7.0 (singlet, 1H); 6.25 (wide singlet, 1H); 3.5 to 3.3 (unresolved peaks, 6H); 2.75 (multiplet, 4H); 2.55 (wide triplet, 2H); 1.9 to 1.7 (unresolved peaks, 4H)
 

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