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Chemical Structure| 81151-35-1 Chemical Structure| 81151-35-1

Structure of 81151-35-1

Chemical Structure| 81151-35-1

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Product Details of [ 81151-35-1 ]

CAS No. :81151-35-1
Formula : C12H16FNO
M.W : 209.26
SMILES Code : FC1=CC=C(COC2CCNCC2)C=C1
MDL No. :MFCD08687808

Safety of [ 81151-35-1 ]

Application In Synthesis of [ 81151-35-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 81151-35-1 ]

[ 81151-35-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 20426-80-6 ]
  • [ 81151-35-1 ]
  • 1-(chroman-4-ylmethyl)-4-((4-fluorobenzyl)oxy)piperidine [ No CAS ]
  • 2
  • [ 20426-80-6 ]
  • [ 81151-35-1 ]
  • 1-chroman-4-yl(4-((4-fluorobenzyl)oxy)piperidin-1-yl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
0.16 g With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20℃; for 3h; A. To a solution of <strong>[20426-80-6]chroman-4-carboxylic acid</strong> (100 mg, 0.56 mmol) in DCM (10 mL) was added 4-((4-fluorobenzyl)oxy)piperidine (0.13 g, 0.62 mmol), triethylamine (0.11 g, 1.12 mmol), HOBT (0.03 g, 1.12 mmol) and EDCI (0.2 g, 1.12 mmol). The reaction was stirred at ambient temperature for 3 h. Saturated aqueous NaHCO3 (20 mL) and DCM (100 mL) were added to the reaction vessel and the resulting biphasic mixture was transferred to a separatory funnel. The layers were separated and the organic phase was washed with saturated aqueous NaCl (2 x 20 mL). The combined organics were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to provide chroman-4-yl(4-((4-fluorobenzyl)oxy)piperidin-1-yl)methanone (0.16 g, 0.43 mmol) as a yellow oil.
 

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