808144-32-3|2,3-Difluorophenylacetyl chloride| Ambeed

Yield	Reaction Conditions	Operation in experiment
80%	With thionyl chloride; In dichloromethane; water;	1) Preparation of (2,3-difluorophenyl)acetyl chloride (1) 1.0 mole of <strong>[145689-41-4](2,3-difluorophenyl)acetic acid</strong> is dissolved in dichloromethane and 1.1 mole of thionyl chloride is added. The mixture is heated to 35 C. and stirred for 4 hours. After completion of the reaction, water is added. The resulting compound is extracted with dichloromethane, dried over MgSO4, and filtered. The solvent is evaporated to yield the target compound. (yield 80%) GC mass data: m/z 193 (>99%)
	With oxalyl dichloride;	Example 1 2-(2, 3-DIFLUORO-PHENYL)-1-(LN-PYRROLO [2, 3-B] PYRIDIN-3-Y L)-ETHANONE : Method A: (X =F) [0198] To 7-azaindole (1 g, 8.5 mmol) and AlCl3 (1.2 g, 9.0 mmol) in methlene chloride at 0C was added (2,3-difluorophenyl)-acetyl chloride [prepared by treating (2,3-difluoro-phenyl)-acetic acid (1.5 mg, 8.72 mmol) with oxalyl chloride (0.90 mL) ] in methlene chloride. After stirring at room temperature for 2 hours, the solution was poured into ice water and extracted with methlene chloride, dried (NA2S04), and concentrated to give 300 mg (13% yield) of title compound used without purification. LCMS Rt= 3. 00 minutes, MH 273.1, M-271. 1.

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2,3-Difluorophenylacetyl chloride

CAS No.: 808144-32-3

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[ 808144-32-3 ] Synthesis Path-Downstream 1~2

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