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Chemical Structure| 808127-76-6 Chemical Structure| 808127-76-6

Structure of 808127-76-6

Chemical Structure| 808127-76-6

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Product Details of [ 808127-76-6 ]

CAS No. :808127-76-6
Formula : C8H6BrNO2
M.W : 228.04
SMILES Code : O=C1NCC2=C1C=C(O)C=C2Br
MDL No. :MFCD13177806
InChI Key :BQPRSUFYMWPKEI-UHFFFAOYSA-N
Pubchem ID :21907535

Safety of [ 808127-76-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 808127-76-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 808127-76-6 ]

[ 808127-76-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 808127-76-6 ]
  • [ 109431-87-0 ]
  • (S)-tert-butyl 3-((7-bromo-3-oxoisoindolin-5-yl)oxy)pyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; water; at 0℃; A solution of(R)-N-Boc-3-hydroxypyrrolidine, HCl (490 mg, 2.19 mmol), 4-bromo-6-hydroxyisoindolin-1-one(250 mg, 1.10 mmol) and PPh3 (575 mg, 2.19 mmol) in THF(3 mL) was cooled to 0 oC and treated with DIAD (443 mg, 2.19mmol). The cooling bath was removed and the mixture stirredovernight. The mixture was concentrated and the residue purified bychromatography on SiO2 (7-60% EtOAc/hexanes) to provide the desiredaryl ether intermediate (299 mg, 69% yield). 1H NMR (600 MHz,DMSO-d6) d 8.88 (s, 1 H), 7.40 (s, 1 H), 7.18 (s, 1 H), 5.12(m, 1 H), 4.20 (s, 2 H), 3.35-3.40 (m, 2 H), 3.42-3.50 (m, 2 H), 2.00-2.18 (m,2 H), 1.38 (s, 9 H); MS (EI) Cal’d for C17H21BrN2O4Na[M+Na]+ 419, 421, found 419, 421.
 

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Technical Information

Categories

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[ 808127-76-6 ]

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Indoles

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