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Product Details of [ 80-00-2 ]

CAS No. :80-00-2
Formula : C12H9ClO2S
M.W : 252.72
SMILES Code : O=S(C1=CC=CC=C1)(C2=CC=C(Cl)C=C2)=O
MDL No. :MFCD00007549

Safety of [ 80-00-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302+H312+H332
Precautionary Statements:P280

Application In Synthesis [ 80-00-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 80-00-2 ]

[ 80-00-2 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 14752-66-0 ]
  • potassium phenyltrifluoborate [ No CAS ]
  • [ 80-00-2 ]
YieldReaction ConditionsOperation in experiment
87% With copper(l) iodide; sodium acetate; In 1,2-dichloro-ethane; at 25℃; for 3h; General procedure: A mixture of potassium arylfluoborate (1 mmol), sodium aryl sulfinate (1 mmol), CuI (0.1 mmol), sodium acetate (1.2 mmol) and DCE (2 mL) was stirred at 25 C under air for 3 h. After filtration, the organic phases were evaporated under reduced pressure, and the residue was subjected to flash column chromatography [silica gel, ethyl acetate/petroleum ether (60-90 C) = 1/8] to obtain the desired product.
  • 2
  • [ 591-50-4 ]
  • [ 14752-66-0 ]
  • [ 80-00-2 ]
YieldReaction ConditionsOperation in experiment
80% With C93H189NO41; copper(I) bromide; In water; at 120℃; for 20h; Put iodobenzene (1mmol, 0.204g) into a 30mL test tube with a stopper,Sodium p-chlorobenzenesulfinate (1.2mmol, 0.238g),Surfactant M2070 (0.3mmol, 0.6g),Cuprous bromide (0.13mmol, 0.0186g),Add 10mL of water,The reaction was stirred at 120C for 20 hours.After cooling, 1g of sodium chloride was added, heated to a cloud point of 80C for extraction, heated to a cloud point of 80C for extraction, and separated into a lower water-rich phase and an upper surface-rich phase. Take out the rich surface layer, heat the rich surface phase (containing a large amount of surfactants and reaction substances), centrifuge at high speed to precipitate the surfactant, take the supernatant, and separate the aryl sulfone compound. High performance liquid chromatography proves that the extraction efficiency is 100%. The yield of aryl sulfone product was 80%.
  • 3
  • [ 108-86-1 ]
  • [ 14752-66-0 ]
  • [ 80-00-2 ]
YieldReaction ConditionsOperation in experiment
80% With C93H189NO41; copper(I) bromide; In water; at 110℃; for 16h; Put bromobenzene (1mmol, 0.157g) into a 30mL test tube with stopper,Sodium p-chlorobenzenesulfinate (5mmol, 0.993g),Surfactant M2070 (0.4mmol, 0.8g),Cuprous bromide (0.14mmol, 0.02g),Add 10mL of water,The reaction was stirred at 110C for 16 hours.After cooling, add 0.1g of sodium chloride, heat to 100 cloud point for extraction,Heating to 80C cloud point extraction,The stratification is the lower water-rich phase and the upper surface rich phase.Take out the rich surface layer, heat the rich surface phase (containing a large amount of surfactants and reaction substances), centrifuge at high speed to precipitate the surfactant, take the supernatant, and separate the aryl sulfone compound. High performance liquid chromatography proves that the extraction efficiency is 100%. The yield of aryl sulfone product was 80%.
  • 4
  • [ 80-00-2 ]
  • [ 1082549-89-0 ]
  • 9,9’-(4’-(phenylsulfonyl)-[1,1' -biphenyl]-3,5-diyl)bis(9H-carbazole) [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% General procedure: A mixture of compound 2 (8.08 g, 15.00 mmol), 4,40 -dichlorodiphenylsulfone (1.44 g, 5.00 mmol), potassium carbonate (6.91 g,50.00 mmol) and methyltrioctylammonium chloride (0.2 mL) was dissolvedin toluene (50.0 mL) and H2O (25.0 mL). Then the resultingmixture was degassed with nitrogen for 15 min and tetrakis (triphenylphosphine)palladium (0.46 g, 0.40 mmol) was added to the mixture.After stirring and heating at 130 C under nitrogen for 12 h, the mixturewas poured into water (75.0 mL) and extracted with chloroform (3 15.0 mL). The organic layer was dried over anhydrous MgSO4. Afterremoving solvent, the residue was purified by column chromatographyon silica gel with hexane/DCM at 2:1 by volume as the eluent to give alight yellow powder.
 

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