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Chemical Structure| 79950-39-3 Chemical Structure| 79950-39-3

Structure of 79950-39-3

Chemical Structure| 79950-39-3

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Product Details of [ 79950-39-3 ]

CAS No. :79950-39-3
Formula : C11H12O3
M.W : 192.21
SMILES Code : O=C(OC)C1=CC=CC(O)=C1CC=C
MDL No. :MFCD19441216

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Application In Synthesis of [ 79950-39-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 79950-39-3 ]

[ 79950-39-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 79950-39-3 ]
  • [ 166599-84-4 ]
  • 2
  • [ 79950-39-3 ]
  • [ 166599-84-4 ]
  • [ 412336-05-1 ]
YieldReaction ConditionsOperation in experiment
With diphenylphosphoranyl azide; triethylamine; In tert-butyl alcohol; Using analogous procedures to those described in J. Med. Chem., 1995, 38, 3102-3103, methyl 2-allyl-3-hydroxybenzoate was converted in three steps via methyl 2-hydroxy-2,3-dihydrobenzofuran-4-carboxylate and methyl benzofuran-4-carboxylate into <strong>[166599-84-4]benzofuran-4-carboxylic acid</strong>. A mixture of benzofuran-4carboxylic acid (0.5 g), diphenylphosphoryl azide (1.2 ml), triethylamine (0.79 ml) and tert-butanol (1.5 ml) were stirred and heated to reflux for 18 hours. The mixture was cooled to ambient temperature and partitioned between ethyl acetate and water. The organic phase was washed in turn with water and brine, dried over magnesium sulphate and evaporated. The residue was purified by column chromatography using methylene chloride as eluent. There was thus obtained tert-butyl benzofuran-4-carbamate (0.8 g) as an oil; Mass Spectrum: M+Na+ 256.
 

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