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Chemical Structure| 79286-79-6 Chemical Structure| 79286-79-6
Chemical Structure| 79286-79-6

3-Aminopyrrolidine

CAS No.: 79286-79-6

4.5 *For Research Use Only !

Cat. No.: A624661 Purity: 95%

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Product Details of [ 79286-79-6 ]

CAS No. :79286-79-6
Formula : C4H10N2
M.W : 86.14
SMILES Code : NC1CCNC1
MDL No. :MFCD00059018

Safety of [ 79286-79-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:2735
Packing Group:

Application In Synthesis of [ 79286-79-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 79286-79-6 ]

[ 79286-79-6 ] Synthesis Path-Downstream   1~29

  • 1
  • [ 130435-38-0 ]
  • [ 79286-79-6 ]
  • [ 130435-62-0 ]
  • 2
  • 7-Chloro-6-fluoro-1-(2-fluoro-1,1-dimethyl-ethyl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • [ 79286-79-6 ]
  • [ 130435-91-5 ]
  • 3
  • 6,7-Difluoro-1-(2-fluoro-1-fluoromethyl-1-methyl-ethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester [ No CAS ]
  • [ 79286-79-6 ]
  • [ 130435-65-3 ]
  • 4
  • 7-Chloro-6-fluoro-1-(2-fluoro-1-fluoromethyl-1-methyl-ethyl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • [ 79286-79-6 ]
  • [ 130435-94-8 ]
  • 5
  • 7-Chloro-6-fluoro-1-(2-fluoro-1,1-bis-fluoromethyl-ethyl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • [ 79286-79-6 ]
  • [ 130435-97-1 ]
  • 6
  • [ 79286-79-6 ]
  • 7-Chloro-6-fluoro-1-(4-fluoro-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • [ 132195-48-3 ]
  • 7
  • [ 79286-79-6 ]
  • 7-Chloro-6-fluoro-5-methyl-4-oxo-1-pyridin-3-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-5-methyl-4-oxo-1-pyridin-3-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 8
  • [ 79286-79-6 ]
  • 7-Chloro-6-fluoro-5-methyl-4-oxo-1-pyridin-4-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-5-methyl-4-oxo-1-pyridin-4-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 9
  • [ 79286-79-6 ]
  • [ 146560-53-4 ]
  • [ 146560-56-7 ]
  • 10
  • [ 79286-79-6 ]
  • 7-Chloro-6-fluoro-5-methyl-4-oxo-1-(4-trifluoromethyl-phenyl)-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-5-methyl-4-oxo-1-(4-trifluoromethyl-phenyl)-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 11
  • [ 79286-79-6 ]
  • 7-Chloro-6-fluoro-1-(4-fluoro-2-methoxy-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • [ 146560-54-5 ]
  • 12
  • [ 79286-79-6 ]
  • 7-Chloro-6-fluoro-1-(2-fluoro-4-methoxy-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • [ 146560-55-6 ]
  • 13
  • [ 79286-79-6 ]
  • 7-Chloro-6-fluoro-5-methyl-4-oxo-1-(4-sulfamoyl-phenyl)-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-5-methyl-4-oxo-1-(4-sulfamoyl-phenyl)-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 14
  • [ 79286-79-6 ]
  • 1-(4-Acetylamino-phenyl)-7-chloro-6-fluoro-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 1-(4-Acetylamino-phenyl)-7-((S)-3-amino-pyrrolidin-1-yl)-6-fluoro-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 15
  • [ 79286-79-6 ]
  • 7-Chloro-6-fluoro-5-methyl-4-oxo-1-(2,4,6-trifluoro-phenyl)-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-5-methyl-4-oxo-1-(2,4,6-trifluoro-phenyl)-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 16
  • [ 79286-79-6 ]
  • 7-Chloro-6-fluoro-1-(4-methanesulfonylamino-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-methanesulfonylamino-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester [ No CAS ]
  • 17
  • [ 79286-79-6 ]
  • [ 108118-77-0 ]
  • [ 177751-67-6 ]
  • 18
  • [ 79286-79-6 ]
  • [ 179740-35-3 ]
  • 1-(3-Amino-4-fluoro-phenyl)-7-((S)-3-amino-pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid [ No CAS ]
  • 19
  • [ 79286-79-6 ]
  • [ 535170-26-4 ]
  • 1-(5-Amino-2-fluoro-phenyl)-7-((S)-3-amino-pyrrolidin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid [ No CAS ]
  • 20
  • [ 79286-79-6 ]
  • [ 179739-64-1 ]
  • [ 179739-88-9 ]
  • 21
  • [ 79286-79-6 ]
  • [ 179739-43-6 ]
  • 1-(3-amino-4,6-difluorophenyl)-7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid [ No CAS ]
  • 22
  • [ 79286-79-6 ]
  • [ 179739-41-4 ]
  • 1-(3-amino-4,6-difluorophenyl)-7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In ethanol; N,N-dimethyl-formamide; EXAMPLE 48 1-(3-amino-4,6-difluorophenyl)-7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid To 6,500 mg of N,N-dimethylformamide were added 1,300 mg of 1-(3-amino-4,6-difluorophenyl)-7-chloro-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid, 600 mg of <strong>[79286-79-6](3S)-3-aminopyrrolidine</strong>, and 1,000 mg of triethylamine. The solution was stirred at 90 C. for 1 hour. The reaction solution was allowed to cool down, combined with 25 ml of ethanol, heated at reflux for 5 minutes, and allowed to cool down. The precipitate was collected by filtration and washed with ethanol and then with diisopropyl ether to give 1,410 mg of the title compound.
  • 23
  • [ 79286-79-6 ]
  • [ 179739-45-8 ]
  • 1-(5-Amino-2,4-difluoro-phenyl)-7-((S)-3-amino-pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid [ No CAS ]
  • 24
  • [ 79286-79-6 ]
  • [ 179739-47-0 ]
  • 7-((S)-3-Amino-pyrrolidin-1-yl)-1-(5-amino-2,3,4-trifluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid [ No CAS ]
  • 25
  • [ 79286-79-6 ]
  • [ 179740-21-7 ]
  • 1-(5-Amino-2,4-difluoro-phenyl)-7-((S)-3-amino-pyrrolidin-1-yl)-8-chloro-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid [ No CAS ]
  • 26
  • [ 79286-79-6 ]
  • [ 240813-70-1 ]
  • (S)-2-(3-Amino-1-pyrrolidinyl)-N-(2-chloro-6-methylphenyl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine [ No CAS ]
  • 27
  • 1-[(4-methoxyphenyl)methyl]-2-oxo-3-{1-[(trifluoromethyl)sulfonyl]benzimidazol-2-yl}-6-chloro-4-hydroquinolyl(trifluoromethyl)sulfonate [ No CAS ]
  • [ 79286-79-6 ]
  • Trifluoro-methanesulfonic acid 2-[6-chloro-1-(4-methoxy-benzyl)-2-oxo-4-((S)-pyrrolidin-3-ylamino)-1,2-dihydro-quinolin-3-yl]-benzoimidazol-1-yl ester [ No CAS ]
  • 28
  • [ 79286-79-6 ]
  • [ 407-25-0 ]
  • 2,2,2-Trifluoro-N-[(S)-1-(2,2,2-trifluoro-acetyl)-pyrrolidin-3-yl]-acetamide [ No CAS ]
  • 29
  • [ 403-33-8 ]
  • [ 79286-79-6 ]
  • [ 953435-47-7 ]
YieldReaction ConditionsOperation in experiment
65% With potassium carbonate; In dimethyl sulfoxide; at 130℃; for 18h; Example 37a; (S)-N-(4-Aminobiphenyl-3-yl)-4-(3-aminopyrrolidin-l-yl)benzamide (327); Scheme 37; Step 1 : (SVMethyl 4-(3-aminopyrrolidin-l-v0benzoate (323); [0940] K2CO3 (7.71 g, 55.84 mmol) was added to a solution of (S)-pyrrolidin-3 -amine (5.0 g,58.04 mmol) and methyl 4-fluorobenzoate (8.6 g, 55.81 mmol) in DMSO (20 mL). The reaction mixture was stirred for 18 h at 130 0C in a sealed tube. The reaction mixture was cooled, diluted with AcOEt and H2O, and extracted with AcOEt (3 times). The extract was washed with water,NH4Cl and brine, dried over MgSO4, filtered and concentrated to give the title compound 323(7.98 g, 65% yield) as a pink solid.[0941] 1H NMR (DMSO-de) delta (ppm): 7.75 (d, J = 9.0 Hz, 2H), 6.52 (d, J = 9.0 Hz, 2H), 3.74(s, 3H), 3.60-3.55 (m, IH), 3.45-3.41 (m, 2H), 3.32-3.25 (m, IH), 2.97-2.93 (m, IH), 2.09-2.01(m, IH), 1.72-1.68 (m, IH). LRMS calc. 220.1; found 221.1 (MH)+.
 

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