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Chemical Structure| 791644-59-2 Chemical Structure| 791644-59-2

Structure of 791644-59-2

Chemical Structure| 791644-59-2

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Product Details of [ 791644-59-2 ]

CAS No. :791644-59-2
Formula : C11H9FN2O
M.W : 204.20
SMILES Code : NC1=CC(OC2=CC=CN=C2)=CC(F)=C1
MDL No. :MFCD14636499

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Application In Synthesis of [ 791644-59-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 791644-59-2 ]

[ 791644-59-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 803700-29-0 ]
  • [ 791644-59-2 ]
YieldReaction ConditionsOperation in experiment
With hydrogen;palladium on carbon; In methanol; at 20℃; for 2.0h; A palladium-carbon catalyst was added to a solution of <strong>[803700-29-0]3-(3-fluoro-5-nitrophenoxy)pyridine</strong> (8.0 g) in methanol (70 ml), and the reaction solution was stirred under hydrogen atmosphere at room temperature for 2 hours. The reaction solution was filtered through Celite, and the filtrate was distilled off under reduced pressure to obtain a crude product as a yellow oil.
  • 2
  • [ 26638-43-7 ]
  • [ 791644-59-2 ]
  • [ 1245607-46-8 ]
YieldReaction ConditionsOperation in experiment
With pyridine; at 20℃; To a solution of 3-fluoro-5-(pyridin-3-yloxy)aniline (1.10 g) in pyridine (22 ml), 1.92 g of <strong>[26638-43-7]methyl 2-(chlorosulfonyl)benzoate</strong> was added, and the reaction solution was stirred overnight at room temperature. Water and a saturated aqueous ammonium chloride solution were added to the reaction solution, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with a IN aqueous hydrochloric acid solution and a saturated saline solution and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resultant residue was purified by silica gel chromatography to yield the title compound as a white solid.1 H-NMR(CDCl3)delta:4.03(3H,s),6.43(lH,dt,J=9.4,2.2Hz),6.65-6.67(lH,m),6.75(lH,dt,J=9.4,2.2Hz),7.23-7.31(2H,m),7.57-7.67(2H,m),7.85(lH,dd,J=7.3,1.5Hz),7.91(lH,dd,J=7.8,1.5Hz),8.20(lH,brs),8.28-8 .30(lH,m),8.42(lH,dd,J=4.6,1.7Hz). ESI-MS Found:m/z 403.2[M+H]+
 

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