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Chemical Structure| 787-57-5 Chemical Structure| 787-57-5

Structure of 787-57-5

Chemical Structure| 787-57-5

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Product Details of [ 787-57-5 ]

CAS No. :787-57-5
Formula : C9H7F3N2O4
M.W : 264.16
SMILES Code : CC(NC1=CC=C(OC(F)(F)F)C=C1[N+]([O-])=O)=O
MDL No. :MFCD00052324

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Application In Synthesis of [ 787-57-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 787-57-5 ]

[ 787-57-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 787-57-5 ]
  • [ 2267-23-4 ]
YieldReaction ConditionsOperation in experiment
With methanol; sodium hydroxide; at 20 - 30℃; for 1.08333 - 1.16667h; Step 2; Hydrolysis; A vessel fitted with a mechanical stirrer, a thermometer probe, water cooling bath and an addition funnel was charged with 4-trifluoromethoxy-2-nitroacetanilide (11.0 Kg) and methanol (42 L) with stirring at ambient temperature. 5 N NaOH (10.41 L) was added to the slurry at 20-30 0C with water bath over 5-10 min to give a homogeneous dark amber solution. The reaction mixture was stirred at 25- 30 0C for Ih. After the reaction was complete, water (63 L) was added at 15-25 0C over 40-50 min with ice water bath. After addition of water, the batch was transferred to a 200 L vessel with mechanical stirring. The slurry was stirred at ambient temperature for another 2-3 h before filtration. The yellow solid product was isolated by filtration, and the wet cake was washed with 3:2 water/methanol (2 x 12.5 L) and dried under nitrogen with vacuum suction to give 2-nitro-4-trifluoromethoxyaniline 4.
 

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