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Chemical Structure| 786685-86-7 Chemical Structure| 786685-86-7

Structure of 786685-86-7

Chemical Structure| 786685-86-7

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Product Details of [ 786685-86-7 ]

CAS No. :786685-86-7
Formula : C13H8F2O2
M.W : 234.20
SMILES Code : OC(=O)C1=CC=C(C=C1F)C1=CC=C(F)C=C1
MDL No. :MFCD12859219
Boiling Point : No data available
InChI Key :VHYXMXAOCUVYFJ-UHFFFAOYSA-N
Pubchem ID :46312327

Safety of [ 786685-86-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 786685-86-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 786685-86-7 ]

[ 786685-86-7 ] Synthesis Path-Downstream   1~4

  • 2
  • [ 1765-93-1 ]
  • [ 112704-79-7 ]
  • [ 786685-86-7 ]
YieldReaction ConditionsOperation in experiment
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 110℃; for 5h;Inert atmosphere; General procedure: Under an argon atmosphere, substituted 4-bromobenzoic acid(1 equiv), benzoic acid (1.1 equiv), K2CO3 (2 equiv), Pd[P(Ph)3]4 (0.1equiv) were added to dioxane/H2O (10:1). The mixture was stirredin an 110 C oil bath for 5 h. The reaction mixture was cooled toroom temperature, and the solvent was removed by rotary evaporation.The residue was dissolved in water, and the solution wasacidified with 3 N HCl until the product precipitated. The precipitatewas filtered to afford compounds 8a-n.
  • 3
  • [ 786685-86-7 ]
  • (S)-2-amino-3-(1H-indol-3-yl)-N-(pyridin-4-yl)propanamide hydrochloric acid [ No CAS ]
  • (S)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,4′-difluoro-[1,1′-biphenyl]-4-carboxamide [ No CAS ]
  • 4
  • [ 786685-86-7 ]
  • C9H17N3*ClH [ No CAS ]
  • N-((2S,3S)-1-(1H-imidazole-1-yl)-3-methylpentan-2-yl)-4',3-difluoro-[1,1'-biphenyl]-4-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
61.5% General procedure: To a solution of acid 8a-n (1 equiv) in DMF, HOBt (1.1 equiv),EDCI (1.1 equiv) was added and the mixture was stirred for 1 h atroom temperature. Then, the amino salt 13a-g (1.1 equiv) and DIEA(2.2 equiv) were added, and the reaction was stirred for 4 h and monitored with TLC. The reaction was poured into water andextracted with ethyl acetate three times. The combined organiclayers were dried over Na2SO4 and evaporated in vacuum. Theresidue was purified by silica gel column chromatography(CH3OH:CH2Cl2 = 40:1) to afford the target compounds 14a-ac.
 

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