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Chemical Structure| 78503-67-0 Chemical Structure| 78503-67-0

Structure of 78503-67-0

Chemical Structure| 78503-67-0

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Product Details of [ 78503-67-0 ]

CAS No. :78503-67-0
Formula : C7H12N2O
M.W : 140.18
SMILES Code : N#CCN1CCC(O)CC1
MDL No. :MFCD09745351

Safety of [ 78503-67-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 78503-67-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 78503-67-0 ]

[ 78503-67-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 78503-67-0 ]
  • [ 129999-60-6 ]
YieldReaction ConditionsOperation in experiment
ii) l-(2-Aminoethyl)piperidin-4-ol; Lithium aluminium hydride in THF (43ml, l.OM in THF) was diluted in dry THF (13 mL) and cooled to O0C under nitrogen. The product from step (i) ((4-hydroxypiperidin-l- yl)acetonitrile) (2.Og) in THF (5 mL) was added slowly via syringe. The reaction mixture was heated at reflux for 5 h then cooled to room temperature. Excess hydride was <n="169"/>destroyed by dropwise addition of 1.6 ml of water and 1.6 ml of 15% NaOH, and finally EtOAc was added dropwise until no effervescence was observed. The granular precipitate formed was filtered and washed several times with DCM and EtOAc. The organic layer was dried (MgSO4) and the solvent was evaporated in vacuo to give the subtitle compound as a yellow oil. Yield: 2.OgThis was used in the next step without purification.1H NMR (DMSO) delta 3.44 - 3.37 (m, IH), 2.64 (t,2H), 2.57 (t, 2H), 2.25 - 2.21 (t, 2H), 1.99 - 1.94 (m, 2H), 1.70 - 1.65(m, 2H), 1.40 -1.3 l(m, 2H).
 

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