78315-99-8|5-Methoxy-3,5-dioxopentanoic acid| Ambeed

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CAS No. :	78315-99-8
Formula :	C₆H₈O₅
M.W :	160.12
SMILES Code :	O=C(O)CC(CC(OC)=O)=O
MDL No. :	MFCD20638257
InChI Key :	VJMSLYCJGYWASX-UHFFFAOYSA-N
Pubchem ID :	416086

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Yield	Reaction Conditions	Operation in experiment
	for 1.0h;	To a flask containing 50 g (0.39 mol) of <strong>[10521-08-1]acetonedicarboxylic acid anhydride</strong> was added 160 ml of cold dry MeOH. The monomethylester solution was allowed to stand for 1 h and filtered.. The filtrate of acetonedicarboxylic acid monomethyl ester was used directly in the following condensation reaction.
		20 mmol of <strong>[10521-08-1]2,4,6-trioxotetrahydropyrane</strong> were stirred in 30 mL methanol till dissolution and afterwards cooled to -20 C. 20 mmol of the corresponding amine and 40 mmol pyridine-2-carboxaldehyde dissolved in 20 mL methanol, respectively, were added to the solution in parallel in a way that the reaction temperature does not exceed - 20 C. After stirring for 2 h at -10 C the solvent was removed in vacuo at room temperature. The obtained residue was covered with a small amount of methanol and the product crystallized at 4 C. The analytical and spectroscopic data of 19-24 are in accordance with the ref. 30,31,32,33 Methyl (2'R,6'S)-1'-benzyl-4'-hydroxy-1',2',5',6'-tetrahydro-2,2';6',2''-terpyridine-3'-carboxylate (19): C24H23N3O3 (401.5 g/mol), yield: 33% (53%)31, mp. 155 C (163-164).33
	at 5 - 20℃;	<strong>[10521-08-1]acetonedicarboxylic acid anhydride</strong> (31.4 kg) was added to methanol (100 L) cooled to 5 C. upon vigorous stirring. The resulting solution was kept at ambient temperature for 45 min to ensure that formation of acetone dicarboxylic acid monomethyl ester was complete.

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P337 + P313	IF eye irritation persists: Get medical advice/attention.
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P370 + P378	In case of fire:
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Disposal
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P501	Dispose of contents/container to ...
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CAS No.: 78315-99-8

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CAS No.: 78315-99-8

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[ 78315-99-8 ] Synthesis Path-Downstream 1~3

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed