78155-85-8|Ethyl 5-nitro-1H-indazole-3-carboxylate| Ambeed

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; water; at 20 - 60℃; for 2h;pH ~ 2;	The conversion of ethyl indazole-3-acid to 5-nitroindazole-3-carboxylic acid is essentially the same method as described for methyl 3-nitrobenzoic acid: Kamm, 0.; Segur, J.B. Org. Syn. Coll. Vol 1. 1941, 372. Ethyl indazole-3-carboxylate (73.7 mmol) was dissolved in 20 mL concentrated sulfuric acid and the reaction mixture was cooled to 0 C. A mixture of concentrated sulfuric acid (12 mL) and 70% nitric acid (12 mL) was added dropwise over the course of 1 h. The mixture was stirred for an additional 1 h at 0 C and was poured onto of crushed ice (200 g). The solid was collected by vacuum filtration, washed with several portions of water and dried in vacuo. The dried solid was suspended in 250 mL acetonitrile and the mixture was heated at reflux for 2 h. The mixture was allowed to cool to room temperature and the solid was collected and dried in vacuo to provide ethyl 5-nitroindazole-3-carboxylate (53%) as a colorless solid. The ester was added to a solution of 10 N sodium hydroxide and the suspension was warmed to 60 C. After 2 h the solution was allowed to cool to room temperature and was acidified to pH - 2.. The precipitated solids were collected by filtration, washed with water, and dried to provide the acid as a light yellow solid. The acid was coupled with 1,4-diazabicyclo[3.2.2]nonane according to procedure A.
	With sodium hydroxide; water;	Ethyl indazole-3-carboxylate (73.7 mmol) was dissolved in 20 mL concentrated sulfuric acid and the reaction mixture was cooled to 0 C. A mixture of concentrated sulfuric acid (12 mL) and 70% nitric acid (12 mL) was added dropwise over the course of 1 h. The mixture was stirred for an additional 1 h at 0 C and was poured onto of crushed ice (200 g). The solid was collected by vacuum filtration, washed with several portions of water and dried in vacuo. The dried solid was suspended in 250 mL acetonitrile and the mixture was heated at reflux for 2 h. The mixture was allowed to cool to room temperature and the solid was collected and dried in vacuo, thus providing ethyl 5- nitroindazole-3-carboxylate in 53% yield as a colorless solid and ethyl 7-nitroindazole-3- carboxylate (5%) as a colorless solid. The esters were saponified using sodium hydroxide to provide the acids.

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Ethyl 5-nitro-1H-indazole-3-carboxylate

CAS No.: 78155-85-8

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Product Details of [ 78155-85-8 ]

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Application In Synthesis [ 78155-85-8 ]

[ 78155-85-8 ] Synthesis Path-Downstream 1~2

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H200	Unstable explosive
H201	Explosive; mass explosion hazard
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H226	Flammable liquid and vapour
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
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H242	Heating may cause a fire
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