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Chemical Structure| 7778-42-9 Chemical Structure| 7778-42-9

Structure of Sulfamoyl Chloride
CAS No.: 7778-42-9

Chemical Structure| 7778-42-9

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Product Details of [ 7778-42-9 ]

CAS No. :7778-42-9
Formula : ClH2NO2S
M.W : 115.54
SMILES Code : O=S(N)(Cl)=O
MDL No. :MFCD11519990
InChI Key :QAHVHSLSRLSVGS-UHFFFAOYSA-N
Pubchem ID :24499

Safety of [ 7778-42-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P422-P303+P361+P353-P210-P402+P404-P411-P501-P260-P301+P330+P331-P305+P351+P338
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 7778-42-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7778-42-9 ]

[ 7778-42-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 38222-83-2 ]
  • [ 20281-23-6 ]
  • [ 7778-42-9 ]
  • 2'-nitrobiphenyl-4-yl sulfamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
In hexane; dichloromethane; water; ethyl acetate; Example 2 108 mg of 2'-nitrobiphenyl-4-ol was dissolved in 9.5 ml of methylene chloride, and 312 mg of <strong>[38222-83-2]2,6-di-tert-butyl-4-methylpyridine</strong> and 347 mg of sulfamoyl chloride were successively added thereto under cooling with ice, followed by stirring at room temperature for 5 hours. After water was added to the reaction mixture, the product was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the resulting crude product was purified by TLC (using a 1:1 mixture of ethyl acetate and hexane as the developing solvent) to obtain 149 mg of 2'-nitrobiphenyl-4-yl sulfamate.
  • 2
  • [ 1204-79-1 ]
  • [ 7778-42-9 ]
  • [ 319015-80-0 ]
YieldReaction ConditionsOperation in experiment
With sodium chloride; In tetrahydrofuran; chloroform; N,N-dimethyl acetamide; Example 96 43 mg of 4'-aminobiphenyl-4-ol was dissolved in 0.7 ml of N,N-dimethylacetamide, and 107 mg of sulfamoyl chloride was added thereto under cooling with ice, followed by stirring at room temperature for 2.4 hours. After the reaction mixture was poured into a saturated aqueous solution of sodium chloride, the product was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the resulting crude product was purified by TLC (using a 17:10 mixture of chloroform and tetrahydrofuran as the developing solvent) to obtain 42 mg of 4'-(sulfamoylamino)biphenyl-4-yl sulfamate. 1H-NMR(CD3OD, δ): 7.30(2H, d, J=8.7Hz), 7.37(2H, d, J=8.7Hz), 7.56(2H, d, J=8.7Hz), 7.63(2H, d, J=8.7Hz). MS(m/z): 343(M+), 264, 184.
 

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