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Chemical Structure| 774-07-2 Chemical Structure| 774-07-2

Structure of 774-07-2

Chemical Structure| 774-07-2

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Product Details of [ 774-07-2 ]

CAS No. :774-07-2
Formula : C7H9N3O2S
M.W : 199.23
SMILES Code : O=C(C1=C(N)NC(N=C1)=S)OCC
MDL No. :MFCD00614345
InChI Key :DKTWKRWWQKVQQB-UHFFFAOYSA-N
Pubchem ID :759149

Safety of [ 774-07-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 774-07-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 774-07-2 ]

[ 774-07-2 ] Synthesis Path-Downstream   1~35

  • 1
  • [ 4637-24-5 ]
  • [ 774-07-2 ]
  • [ 776-53-4 ]
  • 2
  • [ 774-07-2 ]
  • [ 98071-60-4 ]
  • 3
  • [ 123-75-1 ]
  • [ 110-78-1 ]
  • [ 774-07-2 ]
  • 3-propyl-7-pyrrolidin-1-yl-1H-pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione [ No CAS ]
  • 4
  • [ 123-75-1 ]
  • [ 16744-98-2 ]
  • [ 774-07-2 ]
  • 3-(2-fluorophenyl)-7-pyrrolidin-1-yl-1H-pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione [ No CAS ]
  • 5
  • [ 123-75-1 ]
  • [ 103-71-9 ]
  • [ 7051-34-5 ]
  • [ 774-07-2 ]
  • 1-cyclopropylmethyl-3-phenyl-7-pyrrolidin-1-yl-1<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidine-2,4-dione [ No CAS ]
  • 6
  • [ 123-75-1 ]
  • [ 103-71-9 ]
  • [ 2550-36-9 ]
  • [ 774-07-2 ]
  • 1-cyclohexylmethyl-3-phenyl-7-pyrrolidin-1-yl-1<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidine-2,4-dione [ No CAS ]
  • 7
  • [ 123-75-1 ]
  • [ 103-71-9 ]
  • [ 17201-43-3 ]
  • [ 774-07-2 ]
  • 4-(2,4-dioxo-3-phenyl-7-pyrrolidin-1-yl-3,4-dihydro-2<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidin-1-ylmethyl)-benzonitrile [ No CAS ]
  • 8
  • [ 123-75-1 ]
  • [ 103-71-9 ]
  • [ 774-07-2 ]
  • 3-phenyl-7-pyrrolidin-1-yl-1H-pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione [ No CAS ]
  • 9
  • [ 123-75-1 ]
  • [ 103-71-9 ]
  • [ 774-07-2 ]
  • [ 5332-06-9 ]
  • 4-(2,4-dioxo-3-phenyl-7-pyrrolidin-1-yl-3,4-dihydro-2<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidin-1-yl)-butyronitrile [ No CAS ]
  • 10
  • [ 123-75-1 ]
  • [ 16744-98-2 ]
  • [ 17201-43-3 ]
  • [ 774-07-2 ]
  • 4-[3-(2-fluorophenyl)-2,4-dioxo-7-pyrrolidin-1-yl-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-2-ylmethyl]benzonitrile [ No CAS ]
  • 11
  • [ 123-75-1 ]
  • [ 56753-76-5 ]
  • [ 17201-43-3 ]
  • [ 774-07-2 ]
  • 2-[1-(4-cyano-benzyl)-2,4-dioxo-7-pyrrolidin-1-yl-1,4-dihydro-2<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidin-3-yl]-3-phenyl-propionic acid methyl ester [ No CAS ]
  • 12
  • [ 123-75-1 ]
  • [ 16744-98-2 ]
  • [ 774-07-2 ]
  • [ 5332-06-9 ]
  • 4-[3-(2-fluoro-phenyl)-2,4-dioxo-7-pyrrolidin-1-yl-3,4-dihydro-2<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidin-1-yl]-butyronitrile [ No CAS ]
  • 13
  • [ 123-00-2 ]
  • [ 87543-80-4 ]
  • [ 539-74-2 ]
  • [ 774-07-2 ]
  • 2-[1-(2-ethoxycarbonyl-ethyl)-7-(3-morpholin-4-yl-propylamino)-2,4-dioxo-1,4-dihydro-2<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidin-3-yl]-3-phenyl-propionic acid ethyl ester [ No CAS ]
  • 14
  • [ 123-00-2 ]
  • [ 87543-80-4 ]
  • [ 774-07-2 ]
  • 2-[7-(3-morpholin-4-yl-propylamino)-2,4-dioxo-1,4-dihydro-2<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidin-3-yl]-3-phenyl-propionic acid ethyl ester [ No CAS ]
  • 15
  • [ 123-00-2 ]
  • [ 16744-98-2 ]
  • [ 7051-34-5 ]
  • [ 774-07-2 ]
  • 1-cyclopropylmethyl-3-(2-fluoro-phenyl)-7-(3-morpholin-4-yl-propylamino)-1<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidine-2,4-dione [ No CAS ]
  • 16
  • [ 123-00-2 ]
  • [ 456-41-7 ]
  • [ 774-07-2 ]
  • [ 67531-68-4 ]
  • 3-[1-(3-fluoro-benzyl)-7-(3-morpholin-4-yl-propylamino)-2,4-dioxo-1,4-dihydro-2<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidin-3-yl]-benzoic acid ethyl ester [ No CAS ]
  • 17
  • [ 123-00-2 ]
  • [ 87543-80-4 ]
  • [ 17201-43-3 ]
  • [ 774-07-2 ]
  • ethyl 2-[1-(4-cyanobenzyl)-7-(3-morpholin-4-yl-propylamino)-2,4-dioxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-3-phenylpropionate [ No CAS ]
  • 18
  • [ 123-00-2 ]
  • [ 17201-43-3 ]
  • [ 774-07-2 ]
  • [ 67531-68-4 ]
  • 3-[1-(4-cyano-benzyl)-7-(3-morpholin-4-yl-propylamino)-2,4-dioxo-1,4-dihydro-2<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidin-3-yl]-benzoic acid ethyl ester [ No CAS ]
  • 19
  • [ 123-00-2 ]
  • [ 774-07-2 ]
  • [ 67531-68-4 ]
  • [ 5332-06-9 ]
  • 3-[1-(3-cyano-propyl)-7-(3-morpholin-4-yl-propylamino)-2,4-dioxo-1,4-dihydro-2<i>H</i>-pyrimido[4,5-<i>d</i>]pyrimidin-3-yl]-benzoic acid ethyl ester [ No CAS ]
  • 20
  • [ 2706-56-1 ]
  • [ 87543-80-4 ]
  • [ 774-07-2 ]
  • ethyl 2-[2,4-dioxo-7-(2-pyridin-2-ylethylamino)-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-3-phenylpropionate [ No CAS ]
  • 21
  • [ 774-07-2 ]
  • 5-carbamoyl-4-hydroxy-2-mercaptopyrimidine [ No CAS ]
  • 22
  • [ 94-05-3 ]
  • [ 17356-08-0 ]
  • [ 774-07-2 ]
  • 23
  • [ 774-07-2 ]
  • [ 107832-91-7 ]
  • 24
  • [ 774-07-2 ]
  • 4-amino-2-hydrazino-5-methylcarbamoylpyrimidine [ No CAS ]
  • 25
  • [ 774-07-2 ]
  • 3-methyl-7-methylaminopyrimido<4,5-d>pyrimid-4(3H)-one [ No CAS ]
  • 26
  • [ 774-07-2 ]
  • [ 107832-90-6 ]
  • 27
  • [ 774-07-2 ]
  • [ 107832-93-9 ]
  • 28
  • [ 774-07-2 ]
  • [ 107832-96-2 ]
  • 29
  • [ 774-07-2 ]
  • [ 107832-95-1 ]
  • 30
  • [ 774-07-2 ]
  • [ 107832-97-3 ]
  • 31
  • [ 774-07-2 ]
  • 5-amino-6-azidocarbonyltrtrazolo<1,5-a>pyrimidine [ No CAS ]
  • 32
  • [ 774-07-2 ]
  • [ 107832-99-5 ]
  • 33
  • [ 774-07-2 ]
  • C8H8(2)HN5O2 [ No CAS ]
  • 34
  • [ 774-07-2 ]
  • [ 107832-98-4 ]
  • 35
  • [ 774-07-2 ]
  • [ 74-88-4 ]
  • [ 776-53-4 ]
YieldReaction ConditionsOperation in experiment
97% In DMF (N,N-dimethyl-formamide); at 20 - 50℃; for 0.333333h; Iodomethane (2.6 g, 18 mmol) was added to the hot solution (50 C.) of ethyl 4-amino-2-mercaptopyrimidine-5-carboxylate (3.0 g, 15 mmol) in N,N-dimethylformamide (150 mL) and stirred at room temperature for 20 min. Solvent was removed in vacuo and the solid residue was washed by water. After dried in vacuo, desired product was obtained as a white solid (3.1 g, 97%). [0304] HPLC (4 minute gradient) tR=2.14 min; MS m/z 214.1 (M+H)+
45.2 g (86%) With potassium carbonate; In water; acetone; a) A mixture of 49 g (246 mmol) of 4-amino-5-carbethoxypyrimidine-2-thiol and 42 g (304 mmol) of potassium carbonate in 400 ml of acetone was treated with 50 g (352 mmol) of iodomethane. After stirring for 3 hours 500 ml of water were added. The phases were separated and the aqueous phase was extracted twice with 300 ml of dichloromethane each time. The combined organic phases were washed with 100 ml of brine, dried over magnesium sulfate, filtered and evaporated to give 45.2 g (86%) of ethyl 4-amino-2-methylthiopyrimidine-5-carboxylate as a pale yellow solid.
 

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Technical Information

Categories

Related Functional Groups of
[ 774-07-2 ]

Amides

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Related Parent Nucleus of
[ 774-07-2 ]

Pyrimidines

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Ethyl 6-methyl-2-thioxo-1,2-dihydropyrimidine-5-carboxylate

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